Wen-Pei Chang1, Chia-Chin Lin2. 1. Graduate Institute of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, Taipei, Taiwan. 2. School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan. Electronic address: clin@tmu.edu.tw.
Abstract
PURPOSE OF THE RESEARCH: Pain and sleep disturbance have been shown to have a profound influence on the outcomes of cancer treatment. This study sought to determine whether administering opioid analgesics or sleeping medication to cancer patients during their first admission to a hospital is associated with poor prognoses. METHODS AND SAMPLE: We conducted a population-based retrospective cohort study by analyzing data obtained from the National Health Insurance Research Database in Taiwan. The study population comprised cancer patients whose first admission to a hospital for initial cancer treatment was in 2004. KEY RESULTS: We collected data on 2302 cancer patients. To analyze the effect of opioid analgesic and sleeping medication usage on cancer patient survival, we compared the 3-year survival rates among 4 groups of patients (no use, sleeping medications-only, opioid analgesics-only, both used). The 3-year Kaplan-Meier plots for these 4 groups show that the difference was statistically significant (log rank 48.244, p < 0.001). The longevity of cancer patients was the greatest among the no-use group, followed by the sleeping medications-only group, then the opioid analgesics-only group, and finally, the group in which both sleeping medications and opioid analgesics were used. CONCLUSIONS: The use of opioid analgesics or sleeping medication was shown to be negatively correlated with the survival rate of cancer patients.
PURPOSE OF THE RESEARCH: Pain and sleep disturbance have been shown to have a profound influence on the outcomes of cancer treatment. This study sought to determine whether administering opioid analgesics or sleeping medication to cancerpatients during their first admission to a hospital is associated with poor prognoses. METHODS AND SAMPLE: We conducted a population-based retrospective cohort study by analyzing data obtained from the National Health Insurance Research Database in Taiwan. The study population comprised cancerpatients whose first admission to a hospital for initial cancer treatment was in 2004. KEY RESULTS: We collected data on 2302 cancerpatients. To analyze the effect of opioid analgesic and sleeping medication usage on cancerpatient survival, we compared the 3-year survival rates among 4 groups of patients (no use, sleeping medications-only, opioid analgesics-only, both used). The 3-year Kaplan-Meier plots for these 4 groups show that the difference was statistically significant (log rank 48.244, p < 0.001). The longevity of cancerpatients was the greatest among the no-use group, followed by the sleeping medications-only group, then the opioid analgesics-only group, and finally, the group in which both sleeping medications and opioid analgesics were used. CONCLUSIONS: The use of opioid analgesics or sleeping medication was shown to be negatively correlated with the survival rate of cancerpatients.
Authors: A Carmona-Bayonas; P Jiménez-Fonseca; E Castañón; A Ramchandani-Vaswani; R Sánchez-Bayona; A Custodio; D Calvo-Temprano; J A Virizuela Journal: Clin Transl Oncol Date: 2016-07-21 Impact factor: 3.405
Authors: Jason W Boland; Victoria Allgar; Elaine G Boland; Mike I Bennett; Stein Kaasa; Marianne Jensen Hjermstad; Miriam Johnson Journal: Eur J Clin Pharmacol Date: 2019-12-21 Impact factor: 2.953