Literature DB >> 25553540

1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.

Saqlain Haider1, Mohammad Sarwar Alam2, Hinna Hamid3.   

Abstract

Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  1,3,4-Thiadiazole; Anti-inflammatory; Anticancer; Hyperlipidaemia; Mesoionic; Syndones

Mesh：

Substances：

Year:  2014        PMID： 25553540     DOI： 10.1016/j.ejmech.2014.12.035

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  22 in total

1.  The origin of the longer wavelength emission in 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole and its analogue 2-phenylamino-5-(2-hydroxybenzono)-1,3,4-thiadiazole† ‡.

Authors:  Reshmi Dani Ila; Surya Pratap Verma; G Krishnamoorthy
Journal:  Photochem Photobiol Sci       Date:  2020-10-27       Impact factor: 3.982

2.  Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis (azaneylylidene) bis (methaneylylidene) diphenolon Breast Cancer Cells.

Authors:  B M S Saeed; S A N Al-Jadaan; B A Abbas
Journal:  Arch Razi Inst       Date:  2021-10-31

3.  Novel 1,3,4-thiadiazole-chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies.

Authors:  Katarina Jakovljević; Milan D Joksović; Ivana Z Matić; Nina Petrović; Tatjana Stanojković; Dušan Sladić; Miroslava Vujčić; Barbara Janović; Ljubinka Joksović; Snežana Trifunović; Violeta Marković
Journal:  Medchemcomm       Date:  2018-08-23       Impact factor: 3.597

4.  Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells.

Authors:  Gülşen Akalin Çiftçi; Belgin Sever; Mehlika Dilek Altintop
Journal:  Turk J Pharm Sci       Date:  2019-03-27

5.  Spectroscopic Studies of Fluorescence Effects in Bioactive 4-(5-Heptyl-1,3,4-Thiadiazol-2-yl)Benzene-1,3-Diol and 4-(5-Methyl-1,3,4-Thiadiazol-2-yl)Benzene-1,3-Diol Molecules Induced by pH Changes in Aqueous Solutions.

Authors:  Arkadiusz Matwijczuk; Dariusz Kluczyk; Andrzej Górecki; Andrzej Niewiadomy; Mariusz Gagoś
Journal:  J Fluoresc       Date:  2017-03-01       Impact factor: 2.217

6.  5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents.

Authors:  Sobhi M Gomha; Mastoura M Edrees; Zeinab A Muhammad; Ahmed Am El-Reedy
Journal:  Drug Des Devel Ther       Date:  2018-05-30       Impact factor: 4.162

7.  Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents.

Authors:  Mehlika Dilek Altıntop; Özgür Devrim Can; Ümide Demir Özkay; Zafer Asım Kaplancıklı
Journal:  Molecules       Date:  2016-08-01       Impact factor: 4.411

8.  Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan.

Authors:  Zi-Ning Cui; Ya-Sheng Li; De-Kun Hu; Hao Tian; Jia-Zhen Jiang; Yuan Wang; Xiao-Jing Yan
Journal:  Sci Rep       Date:  2016-01-29       Impact factor: 4.379

9.  Spectroscopic and Theoretical Studies of Fluorescence Effects in 2-Methylamino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole Induced by Molecular Aggregation.

Authors:  Arkadiusz Matwijczuk; Andrzej Górecki; Marcin Makowski; Katarzyna Pustuła; Alicja Skrzypek; Joanna Waś; Andrzej Niewiadomy; Mariusz Gagoś
Journal:  J Fluoresc       Date:  2017-09-09       Impact factor: 2.217

10.  Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9.

Authors:  Ahmet Özdemir; Belgin Sever; Mehlika Dilek Altıntop; Halide Edip Temel; Özlem Atlı; Merve Baysal; Fatih Demirci
Journal:  Molecules       Date:  2017-07-04       Impact factor: 4.411
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