Literature DB >> 25553374

Understanding the functional discrepancy of Pim-1 in cancer.

Allal Ouhtit1, Sukalp Muzumdar1, Ishita Gupta1, Somya Shanmuganathan1, Yahya Tamimi1.   

Abstract

The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

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Year:  2015        PMID： 25553374     DOI： 10.2741/E728

Source DB:  PubMed          Journal:  Front Biosci (Elite Ed)        ISSN： 1945-0494


  5 in total

1.  Reduced pim-1 expression increases chemotherapeutic drug sensitivity in human androgen-independent prostate cancer cells by inducing apoptosis.

Authors:  Xing Zhang; Yuyan Sun; Peng Wang; Changfu Yang; Shengwei Li
Journal:  Exp Ther Med       Date:  2019-08-07       Impact factor: 2.447

2.  Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214.

Authors:  Po-Shuan Huang; Yang-Hsiang Lin; Hsiang-Cheng Chi; Pei-Yu Chen; Ya-Hui Huang; Chau-Ting Yeh; Chia-Siu Wang; Kwang-Huei Lin
Journal:  Sci Rep       Date:  2017-11-01       Impact factor: 4.379

3.  Clinical Significance of Pim-1 in Human Cancers: A Meta-analysis of Association with Prognosis and Clinicopathological Characteristics.

Authors:  Lin Lai; Xinyu Chen; Ge Tian; Renba Liang; Xishan Chen; Yuelan Qin; Kaihua Chen; Xiaodong Zhu
Journal:  Cancer Control       Date:  2022 Jan-Dec       Impact factor: 2.339

4.  Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2.

Authors:  Bo-Wei Wang; Chih-Hao Huang; Liang-Chih Liu; Fang-Ju Cheng; Ya-Ling Wei; Yueh-Ming Lin; Yu-Fei Wang; Ching-Ting Wei; Yeh Chen; Yun-Ju Chen; Wei-Chien Huang
Journal:  Front Pharmacol       Date:  2021-06-29       Impact factor: 5.810

5.  In vitro assessment of the efficiency of the PIM-1 kinase pharmacological inhibitor as a potential treatment for Burkitt's lymphoma.

Authors:  Mona Alsubaie; Sabine Matou-Nasri; Abdullah Aljedai; Ahmed Alaskar; Hamad Al-Eidi; Sarah A Albabtain; Khawlah E Aldilaijan; Manal Alsayegh; Ibrahim B Alabdulkareem
Journal:  Oncol Lett       Date:  2021-06-29       Impact factor: 2.967
  5 in total

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