Literature DB >> 25552957

Drosophila melanogaster show a threshold effect in response to radiation.

Michael Antosh1, David Fox1, Thomas Hasselbacher1, Robert Lanou2, Nicola Neretti3, Leon N Cooper4.   

Abstract

We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.

Entities:  

Keywords:  Drosophila melanogaster; gene expression; low dose radiation; threshold effect

Year:  2014        PMID: 25552957      PMCID: PMC4267449          DOI: 10.2203/dose-response.13-047.Antosh

Source DB:  PubMed          Journal:  Dose Response        ISSN: 1559-3258            Impact factor:   2.658


  43 in total

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3.  Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms.

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Review 4.  Circadian rhythm connections to oxidative stress: implications for human health.

Authors:  Melissa Wilking; Mary Ndiaye; Hasan Mukhtar; Nihal Ahmad
Journal:  Antioxid Redox Signal       Date:  2013-04-24       Impact factor: 8.401

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6.  Reactive oxygen species: destroyers or messengers?

Authors:  Grzegorz Bartosz
Journal:  Biochem Pharmacol       Date:  2008-11-24       Impact factor: 5.858

Review 7.  Reactive oxygen species and peroxisomes: struggling for balance.

Authors:  Nina A Bonekamp; Alfred Völkl; H Dariush Fahimi; Michael Schrader
Journal:  Biofactors       Date:  2009 Jul-Aug       Impact factor: 6.113

8.  Cross-life stage and cross-generational effects of gamma irradiations at the egg stage on Drosophila melanogaster life histories.

Authors:  Alexander M Vaiserman; Natalya M Koshel; Ludmila V Mechova; Vladimir P Voitenko
Journal:  Biogerontology       Date:  2004       Impact factor: 4.277

9.  FlyBase 101--the basics of navigating FlyBase.

Authors:  Peter McQuilton; Susan E St Pierre; Jim Thurmond
Journal:  Nucleic Acids Res       Date:  2011-11-29       Impact factor: 16.971

10.  easyRNASeq: a bioconductor package for processing RNA-Seq data.

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  4 in total

1.  ALARA, image gently and CT-induced cancer.

Authors:  Mervyn D Cohen
Journal:  Pediatr Radiol       Date:  2015-02-14

2.  Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster.

Authors:  Samana Shrestha; Adam Vanasse; Leon N Cooper; Michael P Antosh
Journal:  J Comput Biol       Date:  2017-10-16       Impact factor: 1.479

3.  Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster.

Authors:  Svetlana Zhikrevetskaya; Darya Peregudova; Anton Danilov; Ekaterina Plyusnina; George Krasnov; Alexey Dmitriev; Anna Kudryavtseva; Mikhail Shaposhnikov; Alexey Moskalev
Journal:  PLoS One       Date:  2015-08-06       Impact factor: 3.240

Review 4.  Are Risks From Medical Imaging Still too Small to Be Observed or Nonexistent?

Authors:  Brant A Ulsh
Journal:  Dose Response       Date:  2015-05-04       Impact factor: 2.658

  4 in total

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