| Literature DB >> 25552957 |
Michael Antosh1, David Fox1, Thomas Hasselbacher1, Robert Lanou2, Nicola Neretti3, Leon N Cooper4.
Abstract
We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.Entities:
Keywords: Drosophila melanogaster; gene expression; low dose radiation; threshold effect
Year: 2014 PMID: 25552957 PMCID: PMC4267449 DOI: 10.2203/dose-response.13-047.Antosh
Source DB: PubMed Journal: Dose Response ISSN: 1559-3258 Impact factor: 2.658