Literature DB >> 25551493

Review of NASA approach to space radiation risk assessments for Mars exploration.

Francis A Cucinotta1.   

Abstract

Long duration space missions present unique radiation protection challenges due to the complexity of the space radiation environment, which includes high charge and energy particles and other highly ionizing radiation such as neutrons. Based on a recommendation by the National Council on Radiation Protection and Measurements, a 3% lifetime risk of exposure-induced death for cancer has been used as a basis for risk limitation by the National Aeronautics and Space Administration (NASA) for low-Earth orbit missions. NASA has developed a risk-based approach to radiation exposure limits that accounts for individual factors (age, gender, and smoking history) and assesses the uncertainties in risk estimates. New radiation quality factors with associated probability distribution functions to represent the quality factor's uncertainty have been developed based on track structure models and recent radiobiology data for high charge and energy particles. The current radiation dose limits are reviewed for spaceflight and the various qualitative and quantitative uncertainties that impact the risk of exposure-induced death estimates using the NASA Space Cancer Risk (NSCR) model. NSCR estimates of the number of "safe days" in deep space to be within exposure limits and risk estimates for a Mars exploration mission are described.

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Year:  2015        PMID: 25551493     DOI: 10.1097/HP.0000000000000255

Source DB:  PubMed          Journal:  Health Phys        ISSN: 0017-9078            Impact factor:   1.316


  19 in total

1.  Space radiobiology needs realistic hypotheses and relevant methodology.

Authors:  Mélanie L Ferlazzo; Nicolas Foray
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-01       Impact factor: 11.205

2.  In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells.

Authors:  C Rodman; G Almeida-Porada; S K George; J Moon; S Soker; T Pardee; M Beaty; P Guida; S P Sajuthi; C D Langefeld; S J Walker; P F Wilson; C D Porada
Journal:  Leukemia       Date:  2016-11-24       Impact factor: 11.528

3.  Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.

Authors:  Tara B Sweet; Sean D Hurley; Michael D Wu; John A Olschowka; Jacqueline P Williams; M Kerry O'Banion
Journal:  Radiat Res       Date:  2016-12-01       Impact factor: 2.841

4.  Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Authors:  Igor Koturbash; Isabelle R Miousse; Vijayalakshmi Sridharan; Etienne Nzabarushimana; Charles M Skinner; Stepan B Melnyk; Oleksandra Pavliv; Martin Hauer-Jensen; Gregory A Nelson; Marjan Boerma
Journal:  Mutat Res       Date:  2016-03-02       Impact factor: 2.433

5.  Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's disease - Implications for space travel.

Authors:  Emil Rudobeck; John A Bellone; Attila Szücs; Kristine Bonnick; Shalini Mehrotra-Carter; Jerome Badaut; Gregory A Nelson; Richard E Hartman; Roman Vlkolinský
Journal:  PLoS One       Date:  2017-11-29       Impact factor: 3.240

6.  Changes in the distribution and function of leukocytes after whole-body iron ion irradiation.

Authors:  Daila S Gridley; Michael J Pecaut
Journal:  J Radiat Res       Date:  2016-07-05       Impact factor: 2.724

7.  Detrimental Effects of Helium Ion Irradiation on Cognitive Performance and Cortical Levels of MAP-2 in B6D2F1 Mice.

Authors:  Jacob Raber; Eileen Ruth S Torres; Tunde Akinyeke; Joanne Lee; Sydney J Weber Boutros; Mitchell S Turker; Amy Kronenberg
Journal:  Int J Mol Sci       Date:  2018-04-20       Impact factor: 5.923

8.  SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy.

Authors:  Michael I Koukourakis; Alexandra Giatromanolaki; Konstantina Fylaktakidou; Efthimios Sivridis; Christos E Zois; Dimitra Kalamida; Achilleas Mitrakas; Stamatia Pouliliou; Ilias V Karagounis; Konstantinos Simopoulos; David J P Ferguson; Adrian L Harris
Journal:  Invest New Drugs       Date:  2018-01-31       Impact factor: 3.850

9.  MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1.

Authors:  Hiroko P Indo; Tsukasa Tomiyoshi; Shigeaki Suenaga; Kazuo Tomita; Hiromi Suzuki; Daisuke Masuda; Masahiro Terada; Noriaki Ishioka; Oleg Gusev; Richard Cornette; Takashi Okuda; Chiaki Mukai; Hideyuki J Majima
Journal:  J Clin Biochem Nutr       Date:  2015-07-11       Impact factor: 3.114

Review 10.  Effect of Oxidative Stress on Cardiovascular System in Response to Gravity.

Authors:  Ken Takahashi; Hiroki Okumura; Rui Guo; Keiji Naruse
Journal:  Int J Mol Sci       Date:  2017-07-04       Impact factor: 5.923

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