Yande Zhou1, Yufang Chen1, Xueqin Cao1, Chunfeng Liu2, Ying Xie1. 1. Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China. 2. Department of Neurology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Institute of Neuroscience, Soochow University Suzhou 215123, China.
Abstract
PURPOSE: To figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism. METHODS: PubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software. RESULTS: Our meta-analysis indicated that plasma Hcy concentrations elevated in OH patients without L-T4 treatment compared with healthy subjects. However, this elevation was not observed in the comparison between patients withSH without L-T4 treatment and healthy subjects. Moreover, plasma Hcy levels were found to be higher in patients with OH without L-T4 treatment than in patients with SH without L-T4 treatment. Finally, plasma Hcy concentrations decreased after L-T4 treatment in patients with SH or OH. CONCLUSIONS: Plasma Hcy status is associated with the severity of hypothyroidism and L-T4 treatment is helpful for patients with hypothyroidism to reduce the plasma Hcy levels.
PURPOSE: To figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism. METHODS: PubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software. RESULTS: Our meta-analysis indicated that plasma Hcy concentrations elevated in OH patients without L-T4 treatment compared with healthy subjects. However, this elevation was not observed in the comparison between patients withSH without L-T4 treatment and healthy subjects. Moreover, plasma Hcy levels were found to be higher in patients with OH without L-T4 treatment than in patients with SH without L-T4 treatment. Finally, plasma Hcy concentrations decreased after L-T4 treatment in patients with SH or OH. CONCLUSIONS: Plasma Hcy status is associated with the severity of hypothyroidism and L-T4 treatment is helpful for patients with hypothyroidism to reduce the plasma Hcy levels.
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