Xuefeng Wang1, Yue Yang1, Yanbing Huang2, Qiongyao Wang3. 1. Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University Guangzhou 510280, China. 2. Department of Obstetrics and Gynecology, Guangzhou First Municipal People's Hospital, Affiliated to Guangzhou Medical College Guangzhou 510180, China. 3. Department of Obstetrics and Gynecology, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
Abstract
OBJECTIVE: To study the distribution of polymorphism of FXIIIVal34Leu gene in patients with polycystic ovary syndrome and to explore its relationship with polycystic ovary syndrome. METHODS: FXIIIVal34Leu genotype of 120 patients with polycystic ovary syndrome (PCOS) and 90 controls was detected, and the endocrine and metabolic conditions of PCOS patients and the control group were analyzed. RESULTS: Body mass index (BMI) of PCOS patients (26.45±5.81) kg/m(2) was higher than the control group (22.33±5.58) kg/m(2), (p=0.00); the androgen level of PCOS group was (0.67±0.85) ng/mL higher than the control group (0.42±0.22) ng/mL, (p=0.02), and the luteinizing hormone (LH) (16.8±3.61 IU/L) level is higher than the control group (9.23±4.67) IU/L, (p=0.01). Frequency of Val34Leu allele in PCOS group was 1.25%, which was not statistically significant compared to the control group (P=0.56). BMI of patients with the genotype of FXIIIVal34Leu was relatively higher (with the average 34±1 kg/m(2)), and serum HDL level was significantly lower (0.23±0.11 mmol/L). Polymorphism of FXIIIVal34Leu gene had no correlation with susceptibility of PCOS. CONCLUSION: Polymorphism of FXIIIA1 gene may be related to metabolism of PCOS patients; the mutation of FXIIIAVal34Leu is not at the common site for PCOS; polymorphism of FXIIIVal34Leu gene may not have correlation with PCOS.
OBJECTIVE: To study the distribution of polymorphism of FXIIIVal34Leu gene in patients with polycystic ovary syndrome and to explore its relationship with polycystic ovary syndrome. METHODS: FXIIIVal34Leu genotype of 120 patients with polycystic ovary syndrome (PCOS) and 90 controls was detected, and the endocrine and metabolic conditions of PCOSpatients and the control group were analyzed. RESULTS: Body mass index (BMI) of PCOSpatients (26.45±5.81) kg/m(2) was higher than the control group (22.33±5.58) kg/m(2), (p=0.00); the androgen level of PCOS group was (0.67±0.85) ng/mL higher than the control group (0.42±0.22) ng/mL, (p=0.02), and the luteinizing hormone (LH) (16.8±3.61 IU/L) level is higher than the control group (9.23±4.67) IU/L, (p=0.01). Frequency of Val34Leu allele in PCOS group was 1.25%, which was not statistically significant compared to the control group (P=0.56). BMI of patients with the genotype of FXIIIVal34Leu was relatively higher (with the average 34±1 kg/m(2)), and serum HDL level was significantly lower (0.23±0.11 mmol/L). Polymorphism of FXIIIVal34Leu gene had no correlation with susceptibility of PCOS. CONCLUSION: Polymorphism of FXIIIA1 gene may be related to metabolism of PCOSpatients; the mutation of FXIIIAVal34Leu is not at the common site for PCOS; polymorphism of FXIIIVal34Leu gene may not have correlation with PCOS.
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