Literature DB >> 25550916

Hyperbaric oxygen therapy reduces apoptosis after spinal cord injury in rats.

Ying Long1, Fang Liang2, Chunjin Gao2, Zhuo Li2, Jing Yang2.   

Abstract

Hyperbaric oxygen therapy (HBOT) protects brain tissue from inflammatory injury by suppressing mitochondrial apoptotic pathways. However, its neuroprotective mechanism via anti-apoptosis in spinal cord injury (SCI) is still unclear. In our study, Male Sprague-Dawley rats were randomly divided into three groups: sham-operated (SH), SCI model, and SCI + HBOT. Rats in each group were randomly divided into four sub-groups in a time-dependent manner (1 day, 3 days, 7 days and 14 days after surgery). Expression of adaptor molecule apoptosis-associated speck-like protein (ASC) and caspase-3 was evaluated at the indicated time after injury. Our data showed that HBOT downregulated expression of ASC in SCI rats at the mRNA and protein levels. HBOT mitigated caspase-3 release in injured spinal cord tissue. We conclude that HBOT prevents inflammation apoptosis after SCI, likely through suppression of ASC and caspase-3.

Entities:  

Keywords:  Hyperbaric oxygen therapy; apoptosis-associated speck-like protein; caspase-3; spinal cord injury

Year:  2014        PMID： 25550916      PMCID： PMC4276174     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  26 in total

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9.  The protective effect of hyperbaric oxygen and Ginkgo biloba extract on Aβ25-35-induced oxidative stress and neuronal apoptosis in rats.

Authors:  Xiaoqiang Tian; Lida Zhang; Jingmei Wang; Jianguo Dai; Shanshan Shen; Lin Yang; Peilin Huang
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  7 in total

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2.  Evaluation of hyperbaric oxygen therapy for spinal cord injury in rats with different treatment course using diffusion tensor imaging.

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3.  Anti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy.

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Journal:  Med Gas Res       Date:  2017-06-30

5.  Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery.

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Journal:  Neural Regen Res       Date:  2015-09       Impact factor: 5.135

6.  Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat.

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Journal:  BMC Neurol       Date:  2017-12-16       Impact factor: 2.474

Review 7.  Macrophage polarization: a key event in the secondary phase of acute spinal cord injury.

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Journal:  J Cell Mol Med       Date:  2016-12-13       Impact factor: 5.310
  7 in total

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