Literature DB >> 25550902

In vitro effect of progesterone on human melanoma (BLM) cell growth.

Pandurangan Ramaraj1, James L Cox1.   

Abstract

Epidemiological data suggest there is a female sex advantage in melanoma skin cancer. Female sex hormones have been attributed to this protection. There has been no experimental evidence to link female sex hormones directly with melanoma protection until our recently published work on mouse melanoma (B16F10) cells. Our recently published work showed that progesterone significantly inhibited mouse melanoma cell growth in vitro. This study was extended to human melanoma (BLM) cells. Research work revealed that progesterone inhibited human melanoma cell growth also in vitro. The mechanism of inhibition was due to autophagy and this effect of progesterone was not mediated through progesterone receptor.

Entities:  

Keywords:  3-methyladenine (3-MA) rescue; Progesterone; RU-486; autophagy; cell growth; human melanoma (BLM) cells; progesterone receptor

Year:  2014        PMID： 25550902      PMCID： PMC4276160     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  21 in total

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Authors:  F Denizot; R Lang
Journal:  J Immunol Methods       Date:  1986-05-22       Impact factor: 2.303

9.  Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells.

Authors:  Chinnaswamy Jagannath; Devin R Lindsey; Subramanian Dhandayuthapani; Yi Xu; Robert L Hunter; N Tony Eissa
Journal:  Nat Med       Date:  2009-03-01       Impact factor: 53.440

10.  Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.

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Journal:  J Cell Biol       Date:  2011-02-21       Impact factor: 10.539
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  7 in total

1.  Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.

Authors:  Bo Li; Yanru Wang; Yinghui Xu; Hongliang Liu; Wendy Bloomer; Dakai Zhu; Christopher I Amos; Shenying Fang; Jeffrey E Lee; Xin Li; Jiali Han; Qingyi Wei
Journal:  Int J Cancer       Date:  2018-01-17       Impact factor: 7.396

Review 2.  Melanoma in pregnancy.

Authors:  Rebecca Still; Shaun Brennecke
Journal:  Obstet Med       Date:  2017-03-20

3.  In-vitro rescue and recovery studies of human melanoma (BLM) cell growth, adhesion and migration functions after treatment with progesterone.

Authors:  Douglas C Leder; Jason R Brown; Pandurangan Ramaraj
Journal:  Int J Clin Exp Med       Date:  2015-08-15

Review 4.  Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility.

Authors:  Monica Marzagalli; Marina Montagnani Marelli; Lavinia Casati; Fabrizio Fontana; Roberta Manuela Moretti; Patrizia Limonta
Journal:  Front Endocrinol (Lausanne)       Date:  2016-10-26       Impact factor: 5.555

5.  Ethinylestradiol and Levonorgestrel as Active Agents in Normal Skin, and Pathological Conditions Induced by UVB Exposure: In Vitro and In Ovo Assessments.

Authors:  Dorina Coricovac; Claudia Farcas; Cristian Nica; Iulia Pinzaru; Sebastian Simu; Dana Stoian; Codruta Soica; Maria Proks; Stefana Avram; Dan Navolan; Catalin Dumitru; Ramona Amina Popovici; Cristina Adriana Dehelean
Journal:  Int J Mol Sci       Date:  2018-11-14       Impact factor: 5.923

6.  Editorial: Role of Sex Steroids and Their Receptor in Cancers.

Authors:  Pia Giovannelli; Pandurangan Ramaraj; Cecilia Williams
Journal:  Front Endocrinol (Lausanne)       Date:  2022-04-06       Impact factor: 6.055

7.  Differential biological effects of dehydroepiandrosterone (DHEA) between mouse (B16F10) and human melanoma (BLM) cell lines.

Authors:  Kumud Joshi; Sherif S Hassan; Pandurangan Ramaraj
Journal:  Dermatoendocrinol       Date:  2017-11-20
  7 in total

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