Literature DB >> 25550343

Inhibitory SMADs: potential regulators of ovarian function.

Qinglei Li1.   

Abstract

Transforming growth factor beta (TGFB) superfamily signaling regulates essential reproductive functions. Dysregulation of TGFB signaling results in cellular and molecular deficiencies in the ovary, leading to reproductive diseases and cancer development. SMAD proteins are canonical TGFB signaling components consisting of receptor-regulated SMADs (SMAD1/2/3/5/9), a common SMAD (SMAD4), and inhibitory SMADs (SMAD6/7). Inhibitory SMADs are negative regulators of TGFB and bone morphogenetic protein signaling, and their reproductive functions are poorly defined. Emerging evidence supports that inhibitory SMADs are potential regulators of ovarian function. Further efforts and new genetic models are needed to unveil the role of inhibitory SMADs in the ovary.
© 2015 by the Society for the Study of Reproduction, Inc.

Entities:  

Keywords:  SMAD6; SMAD7; development; growth factors; ovary

Mesh：

Substances：

Year:  2014        PMID： 25550343      PMCID： PMC4335786          DOI： 10.1095/biolreprod.114.125203

Source DB:  PubMed          Journal:  Biol Reprod        ISSN： 0006-3363            Impact factor:   4.285


  76 in total

1.  Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter.

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Journal:  J Biol Chem       Date:  2000-03-03       Impact factor: 5.157

2.  A role for smad6 in development and homeostasis of the cardiovascular system.

Authors:  K M Galvin; M J Donovan; C A Lynch; R I Meyer; R J Paul; J N Lorenz; V Fairchild-Huntress; K L Dixon; J H Dunmore; M A Gimbrone; D Falb; D Huszar
Journal:  Nat Genet       Date:  2000-02       Impact factor: 38.330

3.  Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.

Authors:  J Heyer; D Escalante-Alcalde; M Lia; E Boettinger; W Edelmann; C L Stewart; R Kucherlapati
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

4.  Smad6 as a transcriptional corepressor.

Authors:  S Bai; X Shi; X Yang; X Cao
Journal:  J Biol Chem       Date:  2000-03-24       Impact factor: 5.157

5.  STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.

Authors:  P K Datta; H L Moses
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

Review 6.  TGFbeta in Cancer.

Authors:  Joan Massagué
Journal:  Cell       Date:  2008-07-25       Impact factor: 41.582

7.  SMAD3 regulates gonadal tumorigenesis.

Authors:  Qinglei Li; Jonathan M Graff; Anne E O'Connor; Kate L Loveland; Martin M Matzuk
Journal:  Mol Endocrinol       Date:  2007-06-26

8.  Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease.

Authors:  Xiao R Huang; Arthur C K Chung; Xiao J Wang; Kar Neng Lai; Hui Y Lan
Journal:  Am J Physiol Renal Physiol       Date:  2008-04-30

9.  Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.

Authors:  Stephanie A Pangas; Xiaohui Li; Lieve Umans; An Zwijsen; Danny Huylebroeck; Carolina Gutierrez; Degang Wang; James F Martin; Soazik P Jamin; Richard R Behringer; Elizabeth J Robertson; Martin M Matzuk
Journal:  Mol Cell Biol       Date:  2007-10-29       Impact factor: 4.272

10.  Structure-function relationship of inhibitory Smads: Structural flexibility contributes to functional divergence.

Authors:  Ramkumar Hariharan; M Radhakrishna Pillai
Journal:  Proteins       Date:  2008-06
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  16 in total

1.  AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

Authors:  Hui Lin; Ying Ying; Yuan-Yuan Wang; Gang Wang; Shan-Shan Jiang; Deqinag Huang; Lingyu Luo; Ye-Guang Chen; Louis C Gerstenfeld; Zhijun Luo
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2017-08-25       Impact factor: 4.739

2.  Transforming growth factor beta signaling and decidual integrity in mice†.

Authors:  Xin Fang; Nan Ni; Yang Gao; John P Lydon; Ivan Ivanov; Monique Rijnkels; Kayla J Bayless; Qinglei Li
Journal:  Biol Reprod       Date:  2020-12-01       Impact factor: 4.285

3.  Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways.

Authors:  Nour M El-Etreby; Amany A Ghazy; Radwaa Rashad
Journal:  J Ovarian Res       Date:  2017-04-20       Impact factor: 4.234

Review 4.  The molecular mechanism of ovarian granulosa cell tumors.

Authors:  Jiaheng Li; Riqiang Bao; Shiwei Peng; Chunping Zhang
Journal:  J Ovarian Res       Date:  2018-02-06       Impact factor: 4.234

5.  Protein Kinase A Inhibitor H89 Attenuates Experimental Proliferative Vitreoretinopathy.

Authors:  Yali Lyu; Wei Xu; Jieping Zhang; Mengwen Li; Qingyi Xiang; Yao Li; Tianhao Tan; Qingjian Ou; Jingfa Zhang; Haibin Tian; Jing-Ying Xu; Caixia Jin; Furong Gao; Juan Wang; Weiye Li; Ao Rong; Lixia Lu; Guo-Tong Xu
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-02-07       Impact factor: 4.799

6.  Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD.

Authors:  Boxian Huang; Jiafeng Lu; Chenyue Ding; Qinyan Zou; Wei Wang; Hong Li
Journal:  Stem Cell Res Ther       Date:  2018-08-09       Impact factor: 6.832

7.  Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension.

Authors:  Shota Sasagawa; Yuhei Nishimura; Hirofumi Sawada; Erquan Zhang; Shiko Okabe; Soichiro Murakami; Yoshifumi Ashikawa; Mizuki Yuge; Koki Kawaguchi; Reiko Kawase; Yoshihide Mitani; Kazuo Maruyama; Toshio Tanaka
Journal:  Front Pharmacol       Date:  2016-06-07       Impact factor: 5.810

8.  IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells.

Authors:  Zhaoxing Dong; Wenlin Tai; Wen Lei; Yin Wang; ZhenKun Li; Tao Zhang
Journal:  BMC Cell Biol       Date:  2016-03-01       Impact factor: 4.241

Review 9.  SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?

Authors:  Xin Fang; Yang Gao; Qinglei Li
Journal:  Biol Reprod       Date:  2016-09-28       Impact factor: 4.285

10.  MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway.

Authors:  Hari Om Pande; Dawit Tesfaye; Michael Hoelker; Samuel Gebremedhn; Eva Held; Christiane Neuhoff; Ernst Tholen; Karl Schellander; Dessie Salilew Wondim
Journal:  J Ovarian Res       Date:  2018-05-01       Impact factor: 4.234
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