Gustavo Henrique Oliveira Rocha1, Renata Sano Lini1, Fernando Barbosa2, Bruno Lemos Batista2,3, Vanessa Cristina de Oliveira Souza2, Samuel Botião Nerilo1, Erika Bando1, Simone Aparecida Galerani Mossini1, Paula Nishiyama4. 1. Laboratório de Toxicologia, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. 2. Laboratório de Toxicologia e Essencialidade de Metais, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, São Paulo, Brazil. 3. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo, Brazil. 4. Laboratório de Toxicologia, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. pnishiyama@uem.br.
Abstract
OBJECTIVES: To statistically analyze serum heavy metal levels in biological samples obtained from vineyard workers from southern Brazil and check for heavy metal exposure due to pesticide use. METHODS: Serum samples were obtained from 54 farmers and 108 healthy unexposed individuals. Samples from the same farmers were obtained at three different time points over a 1-year period. Levels of lead, arsenic, nickel, zinc, manganese and copper were determined for each sample using dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). All results were statistically analyzed using the nonparametric Kruskal-Wallis test (followed by Dunn's post hoc test). RESULTS: Results showed that serum heavy metal levels in farmers were twofold to fourfold higher than in controls. This difference was found for all heavy metals tested and was significant (p < 0.05). Serum metal levels among the farmers also correlated with the frequency of use of pesticides at a specific time of year, which varied according to seasonal conditions influencing the need for pesticide application. CONCLUSIONS: It can be concluded that in the vineyard region assessed, farmers were more susceptible to heavy metal exposure due to pesticide use.
OBJECTIVES: To statistically analyze serum heavy metal levels in biological samples obtained from vineyard workers from southern Brazil and check for heavy metal exposure due to pesticide use. METHODS: Serum samples were obtained from 54 farmers and 108 healthy unexposed individuals. Samples from the same farmers were obtained at three different time points over a 1-year period. Levels of lead, arsenic, nickel, zinc, manganese and copper were determined for each sample using dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). All results were statistically analyzed using the nonparametric Kruskal-Wallis test (followed by Dunn's post hoc test). RESULTS: Results showed that serum heavy metal levels in farmers were twofold to fourfold higher than in controls. This difference was found for all heavy metals tested and was significant (p < 0.05). Serum metal levels among the farmers also correlated with the frequency of use of pesticides at a specific time of year, which varied according to seasonal conditions influencing the need for pesticide application. CONCLUSIONS: It can be concluded that in the vineyard region assessed, farmers were more susceptible to heavy metal exposure due to pesticide use.
Entities:
Keywords:
Heavy metals; Occupational exposure; Pesticides; Viticulture
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