Literature DB >> 25548947

A journey in science: early lessons from the hemoglobin field.

David J Weatherall1.   

Abstract

Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated. In this volume, the Cerami Award Monograph is by David J Weatherall, Founder, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital. A visionary in the field of hemoglobin, this is the story of Professor Weatherall's scientific journey.

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Year:  2014        PMID: 25548947      PMCID: PMC4277548          DOI: 10.2119/molmed.2014.00093

Source DB:  PubMed          Journal:  Mol Med        ISSN: 1076-1551            Impact factor:   6.354


  45 in total

1.  Thalassaemia in a Gurkha family.

Authors:  D J WEATHERALL; F VELLA
Journal:  Br Med J       Date:  1960-06-04

2.  Assembly of the peptide chains of hemoglobin.

Authors:  H M DINTZIS
Journal:  Proc Natl Acad Sci U S A       Date:  1961-03-15       Impact factor: 11.205

Review 3.  Studies in haemoglobin E beta-thalassaemia.

Authors:  Nancy F Olivieri; Giulia M Muraca; Angela O'Donnell; Anuja Premawardhena; Christopher Fisher; David J Weatherall
Journal:  Br J Haematol       Date:  2008-05       Impact factor: 6.998

4.  The molecular basis of α-thalassemia.

Authors:  Douglas R Higgs
Journal:  Cold Spring Harb Perspect Med       Date:  2013-01-01       Impact factor: 6.915

5.  Haemoglobin C protects against clinical Plasmodium falciparum malaria.

Authors:  D Modiano; G Luoni; B S Sirima; J Simporé; F Verra; A Konaté; E Rastrelli; A Olivieri; C Calissano; G M Paganotti; L D'Urbano; I Sanou; A Sawadogo; G Modiano; M Coluzzi
Journal:  Nature       Date:  2001-11-15       Impact factor: 49.962

6.  alpha+-Thalassemia protects children against disease caused by other infections as well as malaria.

Authors:  S J Allen; A O'Donnell; N D Alexander; M P Alpers; T E Peto; J B Clegg; D J Weatherall
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

7.  Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait.

Authors:  Thomas N Williams; Tabitha W Mwangi; Sammy Wambua; Timothy E A Peto; David J Weatherall; Sunetra Gupta; Mario Recker; Bridget S Penman; Sophie Uyoga; Alex Macharia; Jedidah K Mwacharo; Robert W Snow; Kevin Marsh
Journal:  Nat Genet       Date:  2005-10-16       Impact factor: 38.330

8.  Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

Authors:  R A Spritz; P Jagadeeswaran; P V Choudary; P A Biro; J T Elder; J K deRiel; J L Manley; M L Gefter; B G Forget; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

9.  An immune basis for malaria protection by the sickle cell trait.

Authors:  Thomas N Williams; Tabitha W Mwangi; David J Roberts; Neal D Alexander; David J Weatherall; Sammy Wambua; Moses Kortok; Robert W Snow; Kevin Marsh
Journal:  PLoS Med       Date:  2005-05-31       Impact factor: 11.069

10.  Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions.

Authors:  Frédéric B Piel; Simon I Hay; Sunetra Gupta; David J Weatherall; Thomas N Williams
Journal:  PLoS Med       Date:  2013-07-16       Impact factor: 11.069

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