Jiao Wei1, Hua Xu, Jiasheng Dong, Qingfeng Li, Chuanchang Dai. 1. *All the authors are affiliated with the Department of Plastic & Reconstructive Surgery, Ninth Hospital of Shanghai, Jiaotong University School of Medicine, Shanghai, China.
Abstract
BACKGROUND:Botulinum toxin type A (BTX-A) is widely used for the clinical treatment of masseteric hypertrophy. Until now, few reports have discussed how to prolong the duration of its effectiveness. OBJECTIVE: This study evaluated that purposely adjusting the masticatory movements is possible of postponing the masseter muscle rehypertrophy. METHODS:Ninety-eight patients were randomly and equally divided into 2 groups, and 35 U BTX-A per side was injected into the masseters. The thickness and volume of the masticatory muscles were measured by ultrasound and computerized tomography, respectively. Patients in Group 1 were instructed to strengthen their masticatory effort during the denervated atrophic stage of the masseter (the interval was evaluated by real-time ultrasound monitoring), whereas patients in Group 2 were not given this instruction. When the masseter muscle began to recover, patients in both groups were instructed to reduce their chewing. RESULTS: The duration of the masseter muscle rehypertrophy was significantly prolonged in Group 1 patients. The thickness and the volume of the other masticatory muscles were significantly increased in Group 1 but were either slightly decreased or insignificantly different in Group 2. CONCLUSION: Purposely strengthening masticatory muscle movement during the denervated atrophic stage of the masseter can prolong the duration of masseter rehypertrophy.
RCT Entities:
BACKGROUND: Botulinum toxin type A (BTX-A) is widely used for the clinical treatment of masseteric hypertrophy. Until now, few reports have discussed how to prolong the duration of its effectiveness. OBJECTIVE: This study evaluated that purposely adjusting the masticatory movements is possible of postponing the masseter muscle rehypertrophy. METHODS: Ninety-eight patients were randomly and equally divided into 2 groups, and 35 U BTX-A per side was injected into the masseters. The thickness and volume of the masticatory muscles were measured by ultrasound and computerized tomography, respectively. Patients in Group 1 were instructed to strengthen their masticatory effort during the denervated atrophic stage of the masseter (the interval was evaluated by real-time ultrasound monitoring), whereas patients in Group 2 were not given this instruction. When the masseter muscle began to recover, patients in both groups were instructed to reduce their chewing. RESULTS: The duration of the masseter muscle rehypertrophy was significantly prolonged in Group 1 patients. The thickness and the volume of the other masticatory muscles were significantly increased in Group 1 but were either slightly decreased or insignificantly different in Group 2. CONCLUSION: Purposely strengthening masticatory muscle movement during the denervated atrophic stage of the masseter can prolong the duration of masseter rehypertrophy.
Authors: Kyu-Lim Lee; Hyun Jin Cho; Hyungkyu Bae; Hyun Jin Park; Min Sun Park; Hee-Jin Kim Journal: Toxins (Basel) Date: 2020-03-22 Impact factor: 4.546