Literature DB >> 25548606

A man with a fracture from minor trauma.

Siu Ming Yang1, Chor Man Lo1.   

Abstract

BACKGROUND: We commonly encounter fractures secondary to trauma on and off in our daily practice. While it is not uncommon to see fractures due to underlying pathology, we need to be on the alert when patients present atypically because the treatment for pathological fractures is far different from that for simple fractures.
METHODS: We presented a case of left clavicle fracture secondary to minor trauma, in which the initial X-ray shows suspicious lesion around the fracture site and further investigation reveals multiple myeloma. The patient received treatment at the clinical oncology department upon diagnosis. Since he was relatively young and fit, he was started on the induction therapy of VTD, which was followed by high dose melphalan and autologous stem cell transplant.
RESULTS: He is currently free from symptoms and on maintenance thalidomide.
CONCLUSIONS: Though multiple myeloma is not commonly encountered in emergency practice, earlier identification of relatively subtle symptoms can allow early treatment. Missing this diagnosis will delay treatment and produce severe outcome to the patient. We should be on the alert for such important condition.

Entities:  

Keywords:  Multiple myeloma; Neoplasm metastasis; Spontaneous fracture

Year:  2014        PMID: 25548606      PMCID: PMC4272936          DOI: 10.5847/wjem.j.issn.1920-8642.2014.04.011

Source DB:  PubMed          Journal:  World J Emerg Med        ISSN: 1920-8642


  16 in total

1.  Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Authors:  P Moreau; J San Miguel; H Ludwig; H Schouten; M Mohty; M Dimopoulos; M Dreyling
Journal:  Ann Oncol       Date:  2013-08-16       Impact factor: 32.976

Review 2.  Role of vertebral augmentation procedures in the management of vertebral compression fractures in cancer patients.

Authors:  Kamran Aghayev; Ioannis D Papanastassiou; Frank Vrionis
Journal:  Curr Opin Support Palliat Care       Date:  2011-09       Impact factor: 2.302

Review 3.  Multiple myeloma: recognition and management.

Authors:  E D George; R Sadovsky
Journal:  Am Fam Physician       Date:  1999-04-01       Impact factor: 3.292

4.  The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis.

Authors:  Gareth J Morgan; Walter M Gregory; Faith E Davies; Sue E Bell; Alexander J Szubert; Julia M Brown; Nuria N Coy; Gordon Cook; Nigel H Russell; Claudius Rudin; Huw Roddie; Mark T Drayson; Roger G Owen; Fiona M Ross; Graham H Jackson; J Anthony Child
Journal:  Blood       Date:  2011-10-20       Impact factor: 22.113

5.  Pathologic fractures correlate with reduced survival in patients with malignant bone disease.

Authors:  Fred Saad; Allan Lipton; Richard Cook; Yin-Miao Chen; Matthew Smith; Robert Coleman
Journal:  Cancer       Date:  2007-10-15       Impact factor: 6.860

6.  Fracture risk with multiple myeloma: a population-based study.

Authors:  L Joseph Melton; Robert A Kyle; Sara J Achenbach; Ann L Oberg; S Vincent Rajkumar
Journal:  J Bone Miner Res       Date:  2004-11-29       Impact factor: 6.741

Review 7.  Early versus deferred treatment for early stage multiple myeloma.

Authors:  Y He; K Wheatley; O Clark; A Glasmacher; H Ross; B Djulbegovic
Journal:  Cochrane Database Syst Rev       Date:  2003

8.  Multiple myeloma: a clinicopathologic study of 62 consecutively autopsied cases.

Authors:  S B Kapadia
Journal:  Medicine (Baltimore)       Date:  1980-09       Impact factor: 1.889

Review 9.  Multiple myeloma: clinical review and diagnostic imaging.

Authors:  Edgardo J C Angtuaco; Athanasios B T Fassas; Ronald Walker; Rajesh Sethi; Bart Barlogie
Journal:  Radiology       Date:  2004-02-27       Impact factor: 11.105

Review 10.  Pathogenesis of myeloma bone disease.

Authors:  G D Roodman
Journal:  Leukemia       Date:  2008-11-27       Impact factor: 11.528

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  1 in total

Review 1.  Thoracic wall trauma-misdiagnosed lesions on radiographs and usefulness of ultrasound, multidetector computed tomography and magnetic resonance imaging.

Authors:  Xavier Tomas; Catherine Facenda; Nuno Vaz; Edgar Augusto Castañeda; Montserrat Del Amo; Ana Isabel Garcia-Diez; Jaime Pomes
Journal:  Quant Imaging Med Surg       Date:  2017-08
  1 in total

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