Literature DB >> 25548453

Spectrum of Hemoglobinopathies in West Bengal, India: A CE-HPLC Study on 10407 Subjects.

Debasis Mukhopadhyay1, Kaushik Saha2, Moumita Sengupta3, Sumit Mitra3, Chhanda Datta3, Pradip Kumar Mitra3.   

Abstract

Hemoglobinopathies are common genetic disorders of haemoglobin. Identification of these disorders is immensely important epidemiologically and they can be prevented by population screening. The present study was carried out to evaluate the spectrum of hemoglobinopathies in the state of West Bengal by the cation-exchange high-performance liquid chromatography (CE-HPLC). A retrospective, single-center, cross-sectional study was conducted on consecutive 10,407 participants. Out of 10,407 subjects, 8,898 (85.5 %) were diagnosed as normal, 579 (5.6 %) were as β-thalassemia trait (BTT) and 522 (5.0 %) were detected as HbE carrier on HPLC study. Apart from BTT and HbE carrier ten additional variants were encountered. The present study showed that CE-HPLC is a convenient, high-throughput, labour-saving and objective screening tool for early detection and management of hemoglobinopathies.

Entities:  

Keywords:  Haemoglobin A2; High performance liquid chromatography; Screening; West Bengal; β-Thalassemia trait

Year:  2014        PMID： 25548453      PMCID： PMC4275523          DOI： 10.1007/s12288-014-0373-5

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN： 0971-4502            Impact factor:   0.900


  8 in total

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Journal:  Clin Chem       Date:  2004-10       Impact factor: 8.327

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Journal:  Hemoglobin       Date:  2011-10-17       Impact factor: 0.849

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4.  Cation-exchange HPLC evaluated for presumptive identification of hemoglobin variants.

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Journal:  Clin Chem       Date:  1997-01       Impact factor: 8.327

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Journal:  Bull World Health Organ       Date:  1995       Impact factor: 9.408

6.  Screening for thalassemia and other hemoglobinopathies in a tertiary care hospital of West Bengal: implications for population screening.

Authors:  Bhawna Bhutoria Jain; Rabindra Nath Roy; Sulekha Ghosh; Tapan Ghosh; Uma Banerjee; Subodh Kumar Bhattacharya
Journal:  Indian J Public Health       Date:  2012 Oct-Dec

7.  Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: report of 2600 cases.

Authors:  Ritesh Sachdev; Arpita R Dam; Gaurav Tyagi
Journal:  Indian J Pathol Microbiol       Date:  2010 Jan-Mar       Impact factor: 0.740

8.  Spectrum of haemoglobinopathies diagnosed by cation exchange-HPLC & modulating effects of nutritional deficiency anaemias from north India.

Authors:  Seema Rao; Rakhee Kar; Sanjeev Kumar Gupta; Anita Chopra; Renu Saxena
Journal:  Indian J Med Res       Date:  2010-11       Impact factor: 2.375
  8 in total
  5 in total

1.  Spectrum of Hemoglobinopathies: A New Revelation in a Tertiary Care Hospital of Odisha.

Authors:  Gopal Krushna Ray; Rabindra Kumar Jena
Journal:  Indian J Hematol Blood Transfus       Date:  2018-12-01       Impact factor: 0.900

2.  Clinico-Haematological Profile of Hereditary Haemolytic Anaemias in a Tertiary Health Care Hospital in South India.

Authors:  Chaitra Venkataswamy; Am Shanthala Devi
Journal:  J Clin Diagn Res       Date:  2017-06-01

3.  ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India.

Authors:  Debapriya Basu; Suvro Sankha Datta; Celina Montemayor; Prasun Bhattacharya; Krishnendu Mukherjee; Willy A Flegel
Journal:  Transfus Med Hemother       Date:  2017-10-20       Impact factor: 3.747

4.  Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India.

Authors:  Suvro Sankha Datta; Somnath Mukherjee; Biplabendu Talukder; Prasun Bhattacharya; Krishnendu Mukherjee
Journal:  Adv Hematol       Date:  2015-09-06

5.  Prenatal Screening and Diagnosis of ß-Thalassemia in India: Is ARMS-PCR Enough?

Authors:  Shouriyo Ghosh; Sila Chakrabarti; Maitreyee Bhattacharyya
Journal:  Indian J Hematol Blood Transfus       Date:  2020-10-29       Impact factor: 0.915
  5 in total

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