Annachiara Cagnin1, Cinzia Bussè2, Nela Jelcic3, Francesca Gnoato2, Micaela Mitolo4, Paolo Caffarra5. 1. Department of Neurosciences, SNPSRR, University of Padova, Padova, Italy; IRCCS San Camillo Research Hospital, Venice, Italy. Electronic address: annachiara.cagnin@unipd.it. 2. Department of Neurosciences, SNPSRR, University of Padova, Padova, Italy. 3. IRCCS San Camillo Research Hospital, Venice, Italy. 4. Department of Psychology, University of Padova, Padova, Italy. 5. Department of Neuroscience, University of Parma and Center for Cognitive Disorders, AUSL of Parma, Parma, Italy.
Abstract
BACKGROUND: Patients with dementia with Lewy bodies (DLB) may display a different cognitive pattern from Alzheimer's disease (AD) with more severe impairment performing visuospatial/visuoconstructive tasks. The aim of this study was to investigate whether the analysis of the MMSE pentagon copy could be a useful diagnostic screening tool in prodromal DLB. METHODS: Fifty-three patients with Mild Cognitive Impairment (MCI) were followed over 3-years until a diagnosis of DLB (MCI-DLB: n = 30) and AD (MCI-AD: n = 23) were made according to standard criteria. At the first assessment patients underwent a thorough cognitive assessment including the Qualitative Scoring MMSE Pentagon Test (QSPT), the NPI, the UPDRS as well as questionnaires to determine fluctuations and sleep disorders. RESULTS: The percentage of subjects who were unable to determine the correct number of angles in the pentagon copy test was 45.1% of MCI-DLB and 8.3% of MCI-AD patients (sensitivity 41.1%; specificity 91%). Attentive/executive functions and visual-spatial abilities were worse in the MCI-DLB group, while episodic memory impairment was greater in MCI-AD. Subtle extrapyramidal signs (63%) and RBD symptoms (56%) were the most frequent clinical features supporting the diagnosis of MCI-DLB. CONCLUSIONS: We suggest that a poor performance in determining the number of angles when performing the pentagon copying test, together with the presence of subtle extrapyramidal signs and symptoms of RBD may serve as a predictive tool for early DLB.
BACKGROUND:Patients with dementia with Lewy bodies (DLB) may display a different cognitive pattern from Alzheimer's disease (AD) with more severe impairment performing visuospatial/visuoconstructive tasks. The aim of this study was to investigate whether the analysis of the MMSE pentagon copy could be a useful diagnostic screening tool in prodromal DLB. METHODS: Fifty-three patients with Mild Cognitive Impairment (MCI) were followed over 3-years until a diagnosis of DLB (MCI-DLB: n = 30) and AD (MCI-AD: n = 23) were made according to standard criteria. At the first assessment patients underwent a thorough cognitive assessment including the Qualitative Scoring MMSE Pentagon Test (QSPT), the NPI, the UPDRS as well as questionnaires to determine fluctuations and sleep disorders. RESULTS: The percentage of subjects who were unable to determine the correct number of angles in the pentagon copy test was 45.1% of MCI-DLB and 8.3% of MCI-ADpatients (sensitivity 41.1%; specificity 91%). Attentive/executive functions and visual-spatial abilities were worse in the MCI-DLB group, while episodic memory impairment was greater in MCI-AD. Subtle extrapyramidal signs (63%) and RBD symptoms (56%) were the most frequent clinical features supporting the diagnosis of MCI-DLB. CONCLUSIONS: We suggest that a poor performance in determining the number of angles when performing the pentagon copying test, together with the presence of subtle extrapyramidal signs and symptoms of RBD may serve as a predictive tool for early DLB.
Authors: Stefan Van der Stigchel; Jeroen de Bresser; Rutger Heinen; Huiberdina L Koek; Yael D Reijmer; Geert Jan Biessels; Esther van den Berg Journal: Dement Geriatr Cogn Disord Date: 2018-08-24 Impact factor: 2.959
Authors: Jared T Hinkle; Kate Perepezko; Catherine C Bakker; Ted M Dawson; Vanessa Johnson; Zoltan Mari; Cherie L Marvel; Kelly A Mills; Alexander Pantelyat; Olga Pletnikova; Liana S Rosenthal; Melissa D Shepard; Daniel A Stevens; Juan C Troncoso; Jiangxia Wang; Gregory M Pontone Journal: Int J Geriatr Psychiatry Date: 2017-05-16 Impact factor: 3.485
Authors: L Bonanni; A Cagnin; F Agosta; C Babiloni; B Borroni; M Bozzali; A C Bruni; M Filippi; D Galimberti; R Monastero; C Muscio; L Parnetti; D Perani; L Serra; V Silani; P Tiraboschi; A Padovani Journal: Neurol Sci Date: 2016-09-13 Impact factor: 3.307
Authors: Ian G McKeith; Tanis J Ferman; Alan J Thomas; Frédéric Blanc; Bradley F Boeve; Hiroshige Fujishiro; Kejal Kantarci; Cristina Muscio; John T O'Brien; Ronald B Postuma; Dag Aarsland; Clive Ballard; Laura Bonanni; Paul Donaghy; Murat Emre; James E Galvin; Douglas Galasko; Jennifer G Goldman; Stephen N Gomperts; Lawrence S Honig; Manabu Ikeda; James B Leverenz; Simon J G Lewis; Karen S Marder; Mario Masellis; David P Salmon; John Paul Taylor; Debby W Tsuang; Zuzana Walker; Pietro Tiraboschi Journal: Neurology Date: 2020-04-02 Impact factor: 9.910