Literature DB >> 25547350

Effect of reduced oxygen on the antifungal susceptibility of clinically relevant aspergilli.

Ulrike Binder1, Elisabeth Maurer2, Michaela Lackner2, Cornelia Lass-Flörl2.   

Abstract

The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the species, and the growth ability under hypoxia. The activities of antifungals were not significantly altered under hypoxia, except for Aspergillus terreus, for which the activity changed from fungicidal to fungistatic.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25547350      PMCID： PMC4325812          DOI： 10.1128/AAC.04204-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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