Iván J Núñez Gil1, Mireia Andrés2, Manuel Almendro Delia3, Alessandro Sionis4, Ana Martín5, Teresa Bastante6, Juan Gabriel Córdoba Soriano7, José A Linares Vicente8, Silvia González Sucarrats9, Alejandro Sánchez-Grande Flecha10. 1. Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, Spain. Electronic address: ibnsky@yahoo.es. 2. Servicio de Cardiología, Hospital Vall d'Hebron, Barcelona, Spain. 3. Servicio de Cardiología, Hospital Virgen Macarena, Seville, Spain. 4. Unidad de Cuidados Intensivos Cardiológicos, Servicio de Cardiología, Hospital de Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain. 5. Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain. 6. Servicio de Cardiología, Hospital Universitario de la Princesa, Madrid, Spain. 7. Servicio de Cardiología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. 8. Servicio de Cardiología, Hospital Clínico Lozano Blesa, Zaragoza, Spain. 9. Servicio de Cardiología, Hospital Universitario Arnau de Vilanova, Lerida, Spain. 10. Servicio de Cardiología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
Abstract
INTRODUCTION AND AIMS: The etiology and epidemiology of tako-tsubo cardiomyopathy remain uncertain. The symptoms of this condition are often similar to those of myocardial infarction and, although it usually has a good prognosis, it is not without complications. Our aim was to characterize this disease in our setting using a dedicated registry (Spanish REgistry for TAKOtsubo cardiomyopathy). METHODS: The prospective registry included 202 incident patients in 23 hospitals from 2012 to 2013. The patients' clinical characteristics and analytical, echocardiographic, and imaging results were recorded, as were the events during follow-up. Patients were included when the attending physician considered the case proven, and incidence was calculated relative to the catheterizations requested for a presumptive diagnosis of acute coronary syndrome. RESULTS: The patients were predominantly women (90%), with a mean age of 70 years, and many had cardiovascular risk factors, such as hypertension (67%), dyslipidemia (41%), diabetes mellitus (15%), and smoking (15%). The incidence of tako-tsubo cardiomyopathy was 1.2%, and there was no clear weekly or seasonal distribution pattern. Chest pain was the predominant symptom, a triggering factor (emotional, physical, or both) was present in 72%, and most patients consulted within the first 6h after symptom onset. The median duration of hospitalization was 7 days. There were heart failure symptoms in 34.0%, arrhythmia in 26.7%, and 2.4% of patients died. CONCLUSIONS: The incidence of tako-tsubo cardiomyopathy is low. This disease primarily affects postmenopausal women, and occurs after a situation of emotional stress in more than half of affected individuals. It is characterized by anginal pain, shows no seasonal distribution, and has a good prognosis, although it is not without morbidity and mortality.
INTRODUCTION AND AIMS: The etiology and epidemiology of tako-tsubo cardiomyopathy remain uncertain. The symptoms of this condition are often similar to those of myocardial infarction and, although it usually has a good prognosis, it is not without complications. Our aim was to characterize this disease in our setting using a dedicated registry (Spanish REgistry for TAKOtsubo cardiomyopathy). METHODS: The prospective registry included 202 incident patients in 23 hospitals from 2012 to 2013. The patients' clinical characteristics and analytical, echocardiographic, and imaging results were recorded, as were the events during follow-up. Patients were included when the attending physician considered the case proven, and incidence was calculated relative to the catheterizations requested for a presumptive diagnosis of acute coronary syndrome. RESULTS: The patients were predominantly women (90%), with a mean age of 70 years, and many had cardiovascular risk factors, such as hypertension (67%), dyslipidemia (41%), diabetes mellitus (15%), and smoking (15%). The incidence of tako-tsubo cardiomyopathy was 1.2%, and there was no clear weekly or seasonal distribution pattern. Chest pain was the predominant symptom, a triggering factor (emotional, physical, or both) was present in 72%, and most patients consulted within the first 6h after symptom onset. The median duration of hospitalization was 7 days. There were heart failure symptoms in 34.0%, arrhythmia in 26.7%, and 2.4% of patients died. CONCLUSIONS: The incidence of tako-tsubo cardiomyopathy is low. This disease primarily affects postmenopausal women, and occurs after a situation of emotional stress in more than half of affected individuals. It is characterized by anginal pain, shows no seasonal distribution, and has a good prognosis, although it is not without morbidity and mortality.
Authors: Aitor Uribarri; Iván J Núñez-Gil; D Aritza Conty; Oscar Vedia; Manuel Almendro-Delia; Albert Duran Cambra; Agustin C Martin-Garcia; Marisa Barrionuevo-Sánchez; Manuel Martínez-Sellés; Sergio Raposeiras-Roubín; Marta Guillén; Jose Maria Garcia Acuña; Lucía Matute-Blanco; José A Linares Vicente; Alejandro Sánchez Grande Flecha; Mireia Andrés; Alberto Pérez-Castellanos; Javier Lopez-Pais Journal: J Am Heart Assoc Date: 2019-12-13 Impact factor: 5.501
Authors: Javier Lopez-Pais; Bárbara Izquierdo Coronel; Sergio Raposeiras-Roubín; Leyre Álvarez Rodriguez; Oscar Vedia; Manuel Almendro-Delia; Alessandro Sionis; Agustin C Martin-Garcia; Aitor Uribarri; Emilia Blanco; Irene Martín de Miguel; Emad Abu-Assi; David Galán Gil; Manuela Sestayo Fernández; Maria Jesús Espinosa Pascual; Rosa María Agra-Bermejo; Diego López Otero; Jose María García Acuña; Joaquín Jesús Alonso Martín; Jose Ramón Gonzalez-Juanatey; Miguel Ángel Perez de Juan Romero; Iván J Núñez-Gil Journal: Front Cardiovasc Med Date: 2022-03-14
Authors: Alberto Fuensalida; Maurice Cortés; Luigi Gabrielli; Manuel Méndez; Alejandro Martínez; Gonzalo Martínez Journal: World J Cardiol Date: 2018-10-26
Authors: Sara Moscatelli; Fabrizio Montecucco; Federico Carbone; Alberto Valbusa; Laura Massobrio; Italo Porto; Claudio Brunelli; Gian Marco Rosa Journal: Biomed Res Int Date: 2019-10-30 Impact factor: 3.411