LEARNING OBJECTIVE: Discuss the theory of modulation of receptor activity or the blockade of the reuptake of multiple neurotransmitter systems for the future treatment of MDD. Major depressive disorder (MDD) is a serious and often crippling psychiatric illness with a high risk of relapse and treatment resistance. In this article, we discuss the role of the serotonergic system in MDD including our current understanding of how various serotonin (5HT) receptors modulate monoamine neurotransmission and behavior. We also discuss how pharmacologic interventions, including novel and existing antidepressants and atypical antipsychotics, may be utilized to adjust serotonergic neurotransmission and provide more effective treatments for patients with MDD.
LEARNING OBJECTIVE: Discuss the theory of modulation of receptor activity or the blockade of the reuptake of multiple neurotransmitter systems for the future treatment of MDD. Major depressive disorder (MDD) is a serious and often crippling psychiatric illness with a high risk of relapse and treatment resistance. In this article, we discuss the role of the serotonergic system in MDD including our current understanding of how various serotonin (5HT) receptors modulate monoamine neurotransmission and behavior. We also discuss how pharmacologic interventions, including novel and existing antidepressants and atypical antipsychotics, may be utilized to adjust serotonergic neurotransmission and provide more effective treatments for patients with MDD.
Authors: José Vicente Lafuente; Aruna Sharma; Dafin F Muresanu; Asya Ozkizilcik; Z Ryan Tian; Ranjana Patnaik; Hari S Sharma Journal: Mol Neurobiol Date: 2018-01 Impact factor: 5.590
Authors: Rajkumar Verma; Chunxia G Cronin; Jacob Hudobenko; Venugopal R Venna; Louise D McCullough; Bruce T Liang Journal: Brain Behav Immun Date: 2017-07-24 Impact factor: 7.217
Authors: M Gupta; D Neavin; D Liu; J Biernacka; D Hall-Flavin; W V Bobo; M A Frye; M Skime; G D Jenkins; A Batzler; K Kalari; W Matson; S S Bhasin; H Zhu; T Mushiroda; Y Nakamura; M Kubo; L Wang; R Kaddurah-Daouk; R M Weinshilboum Journal: Mol Psychiatry Date: 2016-02-23 Impact factor: 15.992