Angela M Malek1, Aaron Barchowsky2, Robert Bowser3, Terry Heiman-Patterson4, David Lacomis5, Sandeep Rana6, Evelyn O Talbott7. 1. Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA. Electronic address: malek@musc.edu. 2. Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA. Electronic address: aab20@pitt.edu. 3. Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA; Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA. Electronic address: Robert.Bowser@DignityHealth.org. 4. Department of Neurology, College of Medicine, Drexel University, Philadelphia, PA, 19107, USA. Electronic address: Terry.Heiman-Patterson@drexelmed.edu. 5. Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address: lacomisd@upmc.edu. 6. Department of Neurology, School of Medicine, Temple University, Philadelphia, PA, 19122, USA. Electronic address: sunnyrana@aol.com. 7. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address: eot1@pitt.edu.
Abstract
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a serious and rapidly fatal neurodegenerative disorder with an annual incidence of 1-2.6/100,000 persons. Few known risk factors exist although gene-environment interaction is suspected. We investigated the relationship between suspected neurotoxicant hazardous air pollutants (HAPs) exposure and ALS. METHODS: A case-control study involving sporadic ALS cases (n = 51) and matched controls (n = 51) was conducted from 2008 to 2011. Geocoded residential addresses were linked to U.S. EPA NATA data (1999, 2002, and 2005) by census tract. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. RESULTS: Residential exposure to aromatic solvents significantly elevated the risk of ALS among cases compared to controls in 2002 (OR = 5.03, 95% CI: 1.29, 19.53) and 1999 (OR = 4.27, 95% CI: 1.09, 16.79) following adjustment for education, smoking, and other exposure groups. Metals, pesticides, and other HAPs were not associated with ALS. CONCLUSIONS: A potential relationship is suggested between residential ambient air aromatic solvent exposure and risk of ALS in this study.
BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a serious and rapidly fatal neurodegenerative disorder with an annual incidence of 1-2.6/100,000 persons. Few known risk factors exist although gene-environment interaction is suspected. We investigated the relationship between suspected neurotoxicant hazardous air pollutants (HAPs) exposure and ALS. METHODS: A case-control study involving sporadic ALS cases (n = 51) and matched controls (n = 51) was conducted from 2008 to 2011. Geocoded residential addresses were linked to U.S. EPA NATA data (1999, 2002, and 2005) by census tract. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. RESULTS: Residential exposure to aromatic solvents significantly elevated the risk of ALS among cases compared to controls in 2002 (OR = 5.03, 95% CI: 1.29, 19.53) and 1999 (OR = 4.27, 95% CI: 1.09, 16.79) following adjustment for education, smoking, and other exposure groups. Metals, pesticides, and other HAPs were not associated with ALS. CONCLUSIONS: A potential relationship is suggested between residential ambient air aromatic solvent exposure and risk of ALS in this study.
Authors: Peter E A Ash; Uma Dhawan; Samantha Boudeau; Shuwen Lei; Yari Carlomagno; Mark Knobel; Louloua F A Al Mohanna; Steven R Boomhower; M Christopher Newland; David H Sherr; Benjamin Wolozin Journal: Toxicol Sci Date: 2019-01-01 Impact factor: 4.849
Authors: Angeline S Andrew; Tracie A Caller; Rup Tandan; Eric J Duell; Patricia L Henegan; Nicholas C Field; Walter G Bradley; Elijah W Stommel Journal: Neurodegener Dis Date: 2017-01-26 Impact factor: 2.977
Authors: Robbie M Parks; Yanelli Nunez; Arin A Balalian; Elizabeth A Gibson; Johnni Hansen; Ole Raaschou-Nielsen; Matthias Ketzel; Jibran Khan; Jørgen Brandt; Roel Vermeulen; Susan Peters; Jeff Goldsmith; Diane B Re; Marc G Weisskopf; Marianthi-Anna Kioumourtzoglou Journal: Epidemiology Date: 2022-07-29 Impact factor: 4.860