Ahmed Hashim1, Vica Dang2, Shelly Bolotin3, Natasha S Crowcroft4. 1. Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, Canada M5G 1V2. Electronic address: ahmed_basim81@yahoo.com. 2. Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, Canada M5G 1V2. Electronic address: vica.dang@oahpp.ca. 3. Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, Canada M5G 1V2; Dalla Lana School of Public Health, University of Toronto , 155 College St, Toronto, ON, Canada M5T 3M7. Electronic address: shelly.bolotin@oahpp.ca. 4. Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, Canada M5G 1V2; Dalla Lana School of Public Health, University of Toronto , 155 College St, Toronto, ON, Canada M5T 3M7; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto , Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8. Electronic address: natasha.crowcroft@oahpp.ca.
Abstract
BACKGROUND: The number needed to vaccinate (NNV) is a measure that has been widely used in the scientific literature to draw conclusions about the usefulness and cost-effectiveness of various immunization programmes. The main objective of this review is to examine how and why the NNV has been used and reported in the published literature. METHODS: Electronic databases were searched and records were screened against the eligibility criteria by two independent authors. We included papers that reported and interpreted NNV. RESULTS: We identified 27 studies, the designs including observational studies, economic analyses, systematic reviews, and commentaries. The NNV has been used in the literature to describe three main themes: potential benefits of vaccination programmes, cost-effectiveness, and economic analyses, and modelling studies to compare different vaccination strategies. CONCLUSIONS: NNV has been used in a wide variety of ways in the literature, yet there are no defined thresholds for what is a favourable NNV. Furthermore, the generalizability of the NNV is usually limited. Further work is required to determine the most appropriate use of this measure. Crown
BACKGROUND: The number needed to vaccinate (NNV) is a measure that has been widely used in the scientific literature to draw conclusions about the usefulness and cost-effectiveness of various immunization programmes. The main objective of this review is to examine how and why the NNV has been used and reported in the published literature. METHODS: Electronic databases were searched and records were screened against the eligibility criteria by two independent authors. We included papers that reported and interpreted NNV. RESULTS: We identified 27 studies, the designs including observational studies, economic analyses, systematic reviews, and commentaries. The NNV has been used in the literature to describe three main themes: potential benefits of vaccination programmes, cost-effectiveness, and economic analyses, and modelling studies to compare different vaccination strategies. CONCLUSIONS:NNV has been used in a wide variety of ways in the literature, yet there are no defined thresholds for what is a favourable NNV. Furthermore, the generalizability of the NNV is usually limited. Further work is required to determine the most appropriate use of this measure. Crown
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