Literature DB >> 25542828

Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).

Alison M Mondul1, Irene M Shui2, Kai Yu3, Stephanie J Weinstein3, Konstantinos K Tsilidis4, Amit D Joshi2, Antonio Agudo5, Christine D Berg6, Amanda Black3, Julie E Buring7, Daniel I Chasman7, Mia M Gaudet8, Christopher Haiman9, Susan E Hankinson10, Brian E Henderson9, Robert N Hoover3, David J Hunter2, Kay-Tee Khaw11, Tilman Kühn12, Marina Kvaskoff13, Loic Le Marchand14, Sara Lindström2, Marjorie L McCullough8, Kim Overvad15, Petra H Peeters16, Elio Riboli17, Paul M Ridker7, Daniel O Stram9, Malin Sund18, Dimitrios Trichopoulos19, Rosario Tumino20, Elisabete Weiderpass21, Walter Willett22, Peter Kraft2, Regina G Ziegler3, Demetrius Albanes3.   

Abstract

BACKGROUND: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.
METHODS: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.
RESULTS: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.
CONCLUSIONS: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D-related genotypes, and breast cancer risk. IMPACT: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. Cancer Epidemiol Biomarkers Prev; 24(3); 627-30. ©2014 AACR. ©2014 American Association for Cancer Research.

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Year:  2014        PMID： 25542828      PMCID： PMC4355227          DOI： 10.1158/1055-9965.EPI-14-1127

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  8 in total

1.  Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies.

Authors:  Dan Wang; Omar Israel Vélez de-la-Paz; Jun-Xia Zhai; Dian-Wu Liu
Journal:  Tumour Biol       Date:  2013-06-27

Review 2.  A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.

Authors:  D J Hunter; E Riboli; C A Haiman; D Albanes; D Altshuler; S J Chanock; R B Haynes; B E Henderson; R Kaaks; D O Stram; G Thomas; M J Thun; H Blanché; J E Buring; N P Burtt; E E Calle; H Cann; F Canzian; Y C Chen; G A Colditz; D G Cox; A M Dunning; H S Feigelson; M L Freedman; J M Gaziano; E Giovannucci; S E Hankinson; J N Hirschhorn; R N Hoover; T Key; L N Kolonel; P Kraft; L Le Marchand; S Liu; J Ma; S Melnick; P Pharaoh; M C Pike; C Rodriguez; V W Setiawan; M J Stampfer; E Trapido; R Travis; J Virtamo; S Wacholder; W C Willett
Journal:  Nat Rev Cancer       Date:  2005-12       Impact factor: 60.716

Review 3.  The intracrinology of breast cancer.

Authors:  Keely May McNamara; Hironobu Sasano
Journal:  J Steroid Biochem Mol Biol       Date:  2014-04-19       Impact factor: 4.292

4.  Genome-wide association study of circulating vitamin D levels.

Authors:  Jiyoung Ahn; Kai Yu; Rachael Stolzenberg-Solomon; K Claire Simon; Marjorie L McCullough; Lisa Gallicchio; Eric J Jacobs; Alberto Ascherio; Kathy Helzlsouer; Kevin B Jacobs; Qizhai Li; Stephanie J Weinstein; Mark Purdue; Jarmo Virtamo; Ronald Horst; William Wheeler; Stephen Chanock; David J Hunter; Richard B Hayes; Peter Kraft; Demetrius Albanes
Journal:  Hum Mol Genet       Date:  2010-04-23       Impact factor: 6.150

5.  Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium.

Authors:  Alison M Mondul; Irene M Shui; Kai Yu; Ruth C Travis; Victoria L Stevens; Daniele Campa; Frederick R Schumacher; Regina G Ziegler; H Bas Bueno-de-Mesquita; Sonja Berndt; E D Crawford; Susan M Gapstur; J Michael Gaziano; Edward Giovannucci; Christopher A Haiman; Brian E Henderson; David J Hunter; Mattias Johansson; Timothy J Key; Loïc Le Marchand; Sara Lindström; Marjorie L McCullough; Carmen Navarro; Kim Overvad; Domenico Palli; Mark Purdue; Meir J Stampfer; Stephanie J Weinstein; Walter C Willett; Meredith Yeager; Stephen J Chanock; Dimitrios Trichopoulos; Laurence N Kolonel; Peter Kraft; Demetrius Albanes
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2013-02-01       Impact factor: 4.254

6.  Exploring the genetic architecture of circulating 25-hydroxyvitamin D.

Authors:  Linda T Hiraki; Jacqueline M Major; Constance Chen; Marilyn C Cornelis; David J Hunter; Eric B Rimm; Kelly C Simon; Stephanie J Weinstein; Mark P Purdue; Kai Yu; Demetrius Albanes; Peter Kraft
Journal:  Genet Epidemiol       Date:  2012-11-07       Impact factor: 2.135

7.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Authors:  Thomas J Wang; Feng Zhang; J Brent Richards; Bryan Kestenbaum; Joyce B van Meurs; Diane Berry; Douglas P Kiel; Elizabeth A Streeten; Claes Ohlsson; Daniel L Koller; Leena Peltonen; Jason D Cooper; Paul F O'Reilly; Denise K Houston; Nicole L Glazer; Liesbeth Vandenput; Munro Peacock; Julia Shi; Fernando Rivadeneira; Mark I McCarthy; Pouta Anneli; Ian H de Boer; Massimo Mangino; Bernet Kato; Deborah J Smyth; Sarah L Booth; Paul F Jacques; Greg L Burke; Mark Goodarzi; Ching-Lung Cheung; Myles Wolf; Kenneth Rice; David Goltzman; Nick Hidiroglou; Martin Ladouceur; Nicholas J Wareham; Lynne J Hocking; Deborah Hart; Nigel K Arden; Cyrus Cooper; Suneil Malik; William D Fraser; Anna-Liisa Hartikainen; Guangju Zhai; Helen M Macdonald; Nita G Forouhi; Ruth J F Loos; David M Reid; Alan Hakim; Elaine Dennison; Yongmei Liu; Chris Power; Helen E Stevens; Laitinen Jaana; Ramachandran S Vasan; Nicole Soranzo; Jörg Bojunga; Bruce M Psaty; Mattias Lorentzon; Tatiana Foroud; Tamara B Harris; Albert Hofman; John-Olov Jansson; Jane A Cauley; Andre G Uitterlinden; Quince Gibson; Marjo-Riitta Järvelin; David Karasik; David S Siscovick; Michael J Econs; Stephen B Kritchevsky; Jose C Florez; John A Todd; Josee Dupuis; Elina Hyppönen; Timothy D Spector
Journal:  Lancet       Date:  2010-06-10       Impact factor: 79.321

8.  Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study.

Authors:  Rolf Jorde; Henrik Schirmer; Tom Wilsgaard; Ragnar Martin Joakimsen; Ellisiv Bøgeberg Mathiesen; Inger Njølstad; Maja-Lisa Løchen; Yngve Figenschau; Jens Petter Berg; Johan Svartberg; Guri Grimnes
Journal:  PLoS One       Date:  2012-05-23       Impact factor: 3.240
  8 in total
  10 in total

1.  Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium.

Authors:  Song Yao; Stephen A Haddad; Qiang Hu; Song Liu; Kathryn L Lunetta; Edward A Ruiz-Narvaez; Chi-Chen Hong; Qianqian Zhu; Lara Sucheston-Campbell; Ting-Yuan David Cheng; Jeannette T Bensen; Candace S Johnson; Donald L Trump; Christopher A Haiman; Andrew F Olshan; Julie R Palmer; Christine B Ambrosone
Journal:  Int J Cancer       Date:  2015-12-28       Impact factor: 7.396

Review 2.  Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

Authors:  Sylvia Christakos; Puneet Dhawan; Annemieke Verstuyf; Lieve Verlinden; Geert Carmeliet
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312

Review 3.  Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges.

Authors:  Alison M Mondul; Stephanie J Weinstein; Tracy M Layne; Demetrius Albanes
Journal:  Epidemiol Rev       Date:  2017-01-01       Impact factor: 6.222

4.  Vitamin D and prostate cancer prognosis: a Mendelian randomization study.

Authors:  Olivia Trummer; Uwe Langsenlehner; Sabine Krenn-Pilko; Thomas R Pieber; Barbara Obermayer-Pietsch; Armin Gerger; Wilfried Renner; Tanja Langsenlehner
Journal:  World J Urol       Date:  2015-07-25       Impact factor: 4.226

5.  Vitamin D and Cancer: Diversity, Complexity, and Still a Ways to Go.

Authors:  Demetrius Albanes
Journal:  Cancer Prev Res (Phila)       Date:  2015-08

6.  Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study.

Authors:  Tess V Clendenen; Wenzhen Ge; Karen L Koenig; Tomas Axelsson; Mengling Liu; Yelena Afanasyeva; Anne Andersson; Alan A Arslan; Yu Chen; Göran Hallmans; Per Lenner; Tomas Kirchhoff; Eva Lundin; Roy E Shore; Malin Sund; Anne Zeleniuch-Jacquotte
Journal:  PLoS One       Date:  2015-10-21       Impact factor: 3.240

7.  Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.

Authors:  Vasiliki I Dimitrakopoulou; Konstantinos K Tsilidis; Philip C Haycock; Niki L Dimou; Kawthar Al-Dabhani; Richard M Martin; Sarah J Lewis; Marc J Gunter; Alison Mondul; Irene M Shui; Evropi Theodoratou; Katharina Nimptsch; Sara Lindström; Demetrius Albanes; Tilman Kühn; Timothy J Key; Ruth C Travis; Karani Santhanakrishnan Vimaleswaran; Peter Kraft; Brandon L Pierce; Joellen M Schildkraut
Journal:  BMJ       Date:  2017-10-31

8.  Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women.

Authors:  Paulette D Chandler; Deirdre K Tobias; Lu Wang; Stephanie A Smith-Warner; Daniel I Chasman; Lynda Rose; Edward L Giovannucci; Julie E Buring; Paul M Ridker; Nancy R Cook; JoAnn E Manson; Howard D Sesso
Journal:  Nutrients       Date:  2018-01-09       Impact factor: 5.717

9.  Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Authors:  Delores J Grant; Ani Manichaikul; Anthony J Alberg; Elisa V Bandera; Jill Barnholtz-Sloan; Melissa Bondy; Michele L Cote; Ellen Funkhouser; Patricia G Moorman; Lauren C Peres; Edward S Peters; Ann G Schwartz; Paul D Terry; Xin-Qun Wang; Temitope O Keku; Cathrine Hoyo; Andrew Berchuck; Dale P Sandler; Jack A Taylor; Katie M O'Brien; Digna R Velez Edwards; Todd L Edwards; Alicia Beeghly-Fadiel; Nicolas Wentzensen; Celeste Leigh Pearce; Anna H Wu; Alice S Whittemore; Valerie McGuire; Weiva Sieh; Joseph H Rothstein; Francesmary Modugno; Roberta Ness; Kirsten Moysich; Mary Anne Rossing; Jennifer A Doherty; Thomas A Sellers; Jennifer B Permuth-Way; Alvaro N Monteiro; Douglas A Levine; Veronica Wendy Setiawan; Christopher A Haiman; Loic LeMarchand; Lynne R Wilkens; Beth Y Karlan; Usha Menon; Susan Ramus; Simon Gayther; Aleksandra Gentry-Maharaj; Kathryn L Terry; Daniel W Cramer; Ellen L Goode; Melissa C Larson; Scott H Kaufmann; Rikki Cannioto; Kunle Odunsi; John L Etter; Ruea-Yea Huang; Marcus Q Bernardini; Alicia A Tone; Taymaa May; Marc T Goodman; Pamela J Thompson; Michael E Carney; Shelley S Tworoger; Elizabeth M Poole; Diether Lambrechts; Ignace Vergote; Adriaan Vanderstichele; Els Van Nieuwenhuysen; Hoda Anton-Culver; Argyrios Ziogas; James D Brenton; Line Bjorge; Helga B Salvensen; Lambertus A Kiemeney; Leon F A G Massuger; Tanja Pejovic; Amanda Bruegl; Melissa Moffitt; Linda Cook; Nhu D Le; Angela Brooks-Wilson; Linda E Kelemen; Paul D P Pharoah; Honglin Song; Ian Campbell; Diana Eccles; Anna DeFazio; Catherine J Kennedy; Joellen M Schildkraut
Journal:  Cancer Med       Date:  2019-04-18       Impact factor: 4.711

10.  Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.

Authors:  Jing Wen; Jia Li; Xinyuan Liang; Aiping Wang
Journal:  Dis Markers       Date:  2021-05-22       Impact factor: 3.434
  10 in total

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