Literature DB >> 25542698

Quantitative analysis of CDKN2A methylation, mRNA, and p16(INK4a) protein expression in children and adolescents with Burkitt lymphoma: biological and clinical implications.

Marcela Cristina S Robaina1, Roberta Soares Faccion1, Viviane Oliveira Arruda1, Lidia Maria Magalhães de Rezende2, Gisele Moledo Vasconcelos3, Alexandre Gustavo Apa4, Carlos E Bacchi5, Claudete Esteves Klumb6.   

Abstract

CDKN2A is a tumor suppressor gene critical in the cell cycle regulation. Little is known regarding the role of CDKN2A methylation in the pathogenesis of Burkitt lymphoma (BL). CDKN2A methylation was investigated using pyrosequencing in 51 tumor samples. p16(INK4a) mRNA and protein levels were measured using real-time PCR and immunohistochemistry, respectively. CDKN2A methylation was detectable in 72% cases. Nuclear expression of p16(INK4a) was not detected in 41% cases. There was an association between methylation and absence of CDKN2A mRNA (P=0.003). In conclusion, CDKN2A methylation occurs at a high frequency suggesting a role in BL pathogenesis and potential therapeutic implications.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Burkitt lymphoma; CDKN2A; Methylation; Pyrosequencing; Survival; p16(INK4a)

Mesh：

Substances：

Year:  2014        PMID： 25542698     DOI： 10.1016/j.leukres.2014.11.023

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  7 in total

1.  MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells.

Authors:  Luciano Mazzoccoli; Marcela Cristina Robaina; Alexandre Gustavo Apa; Martin Bonamino; Luciana Wernersbach Pinto; Eduardo Queiroga; Carlos E Bacchi; Claudete Esteves Klumb
Journal:  J Cancer Res Clin Oncol       Date:  2018-01-09       Impact factor: 4.553

Review 2.  Epigenetic Control of a Local Chromatin Landscape.

Authors:  Anna M Chiarella; Dongbo Lu; Nathaniel A Hathaway
Journal:  Int J Mol Sci       Date:  2020-01-31       Impact factor: 5.923

3.  Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells.

Authors:  Emilia Białopiotrowicz; Monika Noyszewska-Kania; Neli Kachamakova-Trojanowska; Agnieszka Łoboda; Magdalena Cybulska; Aleksandra Grochowska; Michał Kopczyński; Michał Mikula; Monika Prochorec-Sobieszek; Małgorzata Firczuk; Agnieszka Graczyk-Jarzynka; Radosław Zagożdżon; Adam Ząbek; Piotr Młynarz; Józef Dulak; Patryk Górniak; Maciej Szydłowski; Karolina Pyziak; Justyna Martyka; Agnieszka Sroka-Porada; Ewa Jabłońska; Anna Polak; Piotr Kowalczyk; Anna Szumera-Ciećkiewicz; Bjoern Chapuy; Tomasz Rzymski; Krzysztof Brzózka; Przemysław Juszczyński
Journal:  Cancers (Basel)       Date:  2020-03-03       Impact factor: 6.639

4.  Hallmarks of cancer-the new testament.

Authors:  Sasi S Senga; Richard P Grose
Journal:  Open Biol       Date:  2021-01-20       Impact factor: 6.411

Review 5.  An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs.

Authors:  Debora Bencivenga; Emanuela Stampone; Angela Vastante; Myassar Barahmeh; Fulvio Della Ragione; Adriana Borriello
Journal:  Cells       Date:  2022-04-14       Impact factor: 7.666

6.  Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation.

Authors:  Leni Maylina; Satoshi Kambayashi; Kenji Baba; Masaru Okuda
Journal:  Vet Sci       Date:  2022-07-29

Review 7.  Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer.

Authors:  Ran Zhao; Bu Young Choi; Mee-Hyun Lee; Ann M Bode; Zigang Dong
Journal:  EBioMedicine       Date:  2016-05-03       Impact factor: 8.143
  7 in total

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