| Literature DB >> 25542686 |
Fenqin Zhao1, Qinqin Mai2, Jianghao Ma3, Mei Xu4, Xue Wang4, Tiantian Cui4, Feng Qiu5, Guang Han6.
Abstract
Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triterpenoids (5-20), including 13 lanostane derivatives, 2 lupanes and 1 oleanane-type triterpene were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. Compounds 6, 8, 18 and 20 exhibited strong cytotoxicity against A549 tumor cell lines, with IC50 values of 2.34, 1.63, 8.39 and 5.39μM, respectively. Seven compounds (3, 9, 10, 12, 18-20) exhibited moderate cytotoxicity against A549, HT29, Hela or L1210 tumor cell lines.Entities:
Keywords: 3β-Hydroxy-lanosta-8,24-diene-21-al (PubChem CID: 44581610); Antitumor; Betulin (PubChem CID: 72326); Betulinic acid (PubChem CID: 64971); Inonotsuoxide A (PubChem CID: 44422304); Inonotus obliquus; Inonotusane A; Inonotusane B; Inonotusane C; Inotodiol (PubChem CID: 44422314); Lanosteol (PubChem CID: 246983); Oleanolic acid (PubChem CID: 10494); Trametenolic acid (PubChem CID: 12309443); Triterpenoids
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Year: 2014 PMID： 25542686 DOI： 10.1016/j.fitote.2014.12.005
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882