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Literature DB >> 2554249

Stimulation of Cl/HCO3 exchange in rat duodenal brush border membrane vesicles by cAMP.

Abstract

Brush border membrane vesicles have been used to study the regulation of rat duodenal HCO3 secretion. When vesicles were loaded with cAMP and ATP SITS-sensitive Cl/HCO3 exchange (unidirectional 36Cl influx in response to an outward-facing OH/HCO3 gradient) was stimulated by approximately 25%. In contrast, there was no effect of cAMP upon SITS-insensitive 36Cl uptake. The stimulation of Cl/HCO3 exchange caused by cAMP was abolished in the presence of a specific heat-stable cAMP-dependent protein kinase inhibitor. These results suggest that Cl/HCO3 exchange, and hence HCO3 secretion, is regulated by cAMP via phosphorylation of some component of the membrane associated with the transport protein.

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Year: 1989 PMID： 2554249 DOI： 10.1007/BF00582138

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

19 in total

1. Efficient entrapment of large and small compounds during vesiculation of intestinal microvilli.

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2. Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells.

Authors: R A Schoumacher; R L Shoemaker; D R Halm; E A Tallant; R W Wallace; R A Frizzell
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3. Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases.

Authors: D A Walsh; C D Ashby; C Gonzalez; D Calkins; E H Fischer
Journal: J Biol Chem Date: 1971-04-10 Impact factor: 5.157

4. Adaptation of phosphate transport in phosphate-deprived LLC-PK1 cells.

Authors: J Caverzasio; C D Brown; J Biber; J P Bonjour; H Murer
Journal: Am J Physiol Date: 1985-01

Review 5. Cyclic nucleotides and their role in gastrointestinal secretion.

Authors: D V Kimbert
Journal: Gastroenterology Date: 1974-11 Impact factor: 22.682

6. A simple apparatus for performing short-time (1--2 seconds) uptake measurements in small volumes; its application to D-glucose transport studies in brush border vesicles from rabbit jejunum and ileum.

Authors: M Kessler; V Tannenbaum; C Tannenbaum
Journal: Biochim Biophys Acta Date: 1978-05-18

Stimulation of Cl/HCO3 exchange in rat duodenal brush border membrane vesicles by cAMP.

1. Efficient entrapment of large and small compounds during vesiculation of intestinal microvilli.

2. Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells.

3. Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases.

4. Adaptation of phosphate transport in phosphate-deprived LLC-PK1 cells.

Review 5. Cyclic nucleotides and their role in gastrointestinal secretion.

6. A simple apparatus for performing short-time (1--2 seconds) uptake measurements in small volumes; its application to D-glucose transport studies in brush border vesicles from rabbit jejunum and ileum.

7. Phosphate transport into brush-border membrane vesicles isolated from rat small intestine.

8. Calmodulin-mediated effects of loperamide on chloride transport by brush border membrane vesicles from human ileum.

9. Freeze-thaw and high-voltage discharge allow macromolecule uptake into ileal brush-border vesicles.

10. Rabbit small intestinal brush border membrane preparation and lipid composition.

Review 1. Acid-base transport systems in gastrointestinal epithelia.

2. A Cl- conductance sensitive to external pH in the apical membrane of rat duodenal enterocytes.

3. cAMP-dependent protein kinase inhibits the chloride conductance in apical membrane vesicles of human placenta.

4. Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

5. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.

6. Effect of parathyroid hormone on acid/base transport in rabbit renal proximal tubule S3 segment.

7. Effect of second messenger systems on oxalate uptake in renal epithelial cells.

8. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.