Literature DB >> 25542228

Genetic polymorphisms of DNA repair pathways influence the response to chemotherapy and overall survival of gastric cancer.

Jing Zhou1, Zhi-yue Liu, Cun-bao Li, Shang Gao, Li-hong Ding, Xin-lin Wu, Zhao-yang Wang.   

Abstract

We aimed to evaluate the clinical response to platinum-based chemotherapy and treatment outcome of gastric cancer patients in the present of ERCC1, ERCC2, NBN, RAD51, and XRCC3 gene polymorphisms. A number of 415 patients of gastric cancer that received platinum-based chemotherapy were enrolled in the present study. The presence of ERCC1 rs11615 and rs2298881, ERCC2 rs1799793 and rs13181, NBN rs1805794, rs709816, and RAD51 rs1801321 and XRCC3 rs1799794 were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Conditional regression analysis identified that CC genotype of ERCC1 rs11615 and AA genotype of ERCC2 rs1799793 was associated with a better response to chemotherapy in gastric cancer patients, and the odds ratio (ORs)(95% confidence interval (CI)) were 2.70(1.33-5.70) and 3.12(1.52-6.84), respectively. By the Cox analysis, the CC genotype of ERCC1 rs11615, AA genotype of ERCC2 rs1799793, and CC genotype of NBN rs1805794 were significantly associated with a longer overall survival (OS) of gastric cancer. In conclusion, our results suggest that ERCC1 rs11615, ERCC2 rs1799793, and NBN rs1805794 polymorphisms in the DNA repair pathways may influence the response to chemotherapy and OS of gastric cancer.

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Year:  2014        PMID： 25542228     DOI： 10.1007/s13277-014-2936-3

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  20 in total

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2.  Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients.

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3.  Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer.

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Journal:  Genet Mol Res       Date:  2014-09-12

4.  Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer.

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Journal:  Chin Med J (Engl)       Date:  2014       Impact factor: 2.628

5.  Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer in a Chinese population.

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  12 in total

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Journal:  Int J Clin Exp Pathol       Date:  2015-07-01

2.  The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population.

Authors:  Huansong Gong; He Li; Jing Zou; Jia Mi; Fang Liu; Dan Wang; Dong Yan; Bin Wang; Shuping Zhang; Geng Tian
Journal:  Tumour Biol       Date:  2015-11-21

3.  Genetic variability of genes in NER pathway influences the treatment outcome of gastric cancer.

Authors:  Ming-Hui Xue; Guang-Yan Li; Xin-Jun Wu; Chao-Xian Zhang; Cai-Feng Zhang; Kong-Xi Zhu
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4.  Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

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Journal:  Tumour Biol       Date:  2016-07-27

5.  Prognostic value of ERCC1 and ERCC2 gene polymorphisms in patients with gastric cancer receiving platinum-based chemotherapy.

Authors:  Juanmei Mo; Min Luo; Jiandong Cui; Shaozhang Zhou
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

6.  Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer.

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Journal:  Oncotarget       Date:  2017-04-04

8.  Genetic polymorphisms in ERCC1 and ERCC2 genes are associated with response to chemotherapy in osteosarcoma patients among Chinese population: a meta-analysis.

Authors:  Haiguang Zhang; Junbo Ge; Huanyu Hong; Lili Bi; Zhengwen Sun
Journal:  World J Surg Oncol       Date:  2017-04-07       Impact factor: 2.754

9.  Predictive Value of Two Polymorphisms of ERCC2, rs13181 and rs1799793, in Clinical Outcomes of Chemotherapy in Gastric Cancer Patients: A Meta-Analysis.

Authors:  Mengxi Li; Yan Zhao; Erjiang Zhao; Kunlun Wang; Weiquan Lu; Ling Yuan
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10.  MAP3K1 rs889312 genotypes influence survival outcomes of Chinese gastric cancer patients who received adjuvant chemotherapy based on platinum and fluorouracil regimes.

Authors:  Jian Yang; Wei Zheng; Zhi Xu; Jinfei Chen
Journal:  Onco Targets Ther       Date:  2019-08-22       Impact factor: 4.147
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