Literature DB >> 25542183

A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation.

Wen-fei Wang1, Lei Ma, Ming-yao Liu, Ting-ting Zhao, Tong Zhang, Yong-bi Yang, Hong-xue Cao, Xiao-hui Han, De-shan Li.   

Abstract

Fibroblast growth factor 21 (FGF-21) is a major paracrine and endocrine regulator of metabolic homeostasis. Here we demonstrate that FGF-21 is also a potent mediator of innate immunity. Double-staining flow cytometry identified neutrophils and monocytes as the main sources of FGF-21 among circulating leukocytes. Functional assays showed that FGF-21 stimulates phagocytosis and production of reactive oxygen species in neutrophil-like HL-60 cells and monocytic THP-1 cells. The mechanism of action of FGF-21 was observed to involve FGF receptor activation, signal transduction through the PI3K/Akt pathway, and stimulation of NADPH oxidase activity. This study indicates that FGF-21 could be an attractive target for the management of inflammatory disorders.

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Year:  2014        PMID： 25542183     DOI： 10.1007/s12020-014-0502-9

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  40 in total

1.  Aging: a theory based on free radical and radiation chemistry.

Authors:  D HARMAN
Journal:  J Gerontol       Date:  1956-07

Review 2.  Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases.

Authors:  Mark T Quinn; Katherine A Gauss
Journal:  J Leukoc Biol       Date:  2004-07-07       Impact factor: 4.962

3.  Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).

Authors:  S Tsuchiya; M Yamabe; Y Yamaguchi; Y Kobayashi; T Konno; K Tada
Journal:  Int J Cancer       Date:  1980-08       Impact factor: 7.396

4.  Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells.

Authors:  Alberto Dávalos; Gema de la Peña; Carolina C Sánchez-Martín; M Teresa Guerra; Begoña Bartolomé; Miguel A Lasunción
Journal:  Br J Nutr       Date:  2009-05-19       Impact factor: 3.718

5.  Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

Authors:  S J Collins; F W Ruscetti; R E Gallagher; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

6.  Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

Authors:  C J Vlahos; W F Matter; R F Brown; A E Traynor-Kaplan; P G Heyworth; E R Prossnitz; R D Ye; P Marder; J A Schelm; K J Rothfuss
Journal:  J Immunol       Date:  1995-03-01       Impact factor: 5.422

Review 7.  Activation and assembly of the NADPH oxidase: a structural perspective.

Authors:  Yvonne Groemping; Katrin Rittinger
Journal:  Biochem J       Date:  2005-03-15       Impact factor: 3.857

8.  Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.

Authors:  Zhuofeng Lin; Zhen Wu; Xiaojing Yin; Yanlong Liu; Xinxin Yan; Shaoqiang Lin; Jian Xiao; Xiaojie Wang; Wenke Feng; Xiaokun Li
Journal:  PLoS One       Date:  2010-12-29       Impact factor: 3.240

9.  Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

Authors:  Alberto O Chavez; Marjorie Molina-Carrion; Muhammad A Abdul-Ghani; Franco Folli; Ralph A Defronzo; Devjit Tripathy
Journal:  Diabetes Care       Date:  2009-06-01       Impact factor: 19.112

10.  The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

Authors:  Yuan Zhang; Yang Xie; Eric D Berglund; Katie Colbert Coate; Tian Teng He; Takeshi Katafuchi; Guanghua Xiao; Matthew J Potthoff; Wei Wei; Yihong Wan; Ruth T Yu; Ronald M Evans; Steven A Kliewer; David J Mangelsdorf
Journal:  Elife       Date:  2012-10-15       Impact factor: 8.140
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  5 in total

1.  FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation.

Authors:  Jun-Yan Li; Nan Wang; Mir Hassan Khoso; Cheng-Bin Shen; Meng-Ze Guo; Xin-Xin Pang; De-Shan Li; Wen-Fei Wang
Journal:  Inflammation       Date:  2018-06       Impact factor: 4.092

2.  FGF-21 Plays a Crucial Role in the Glucose Uptake of Activated Monocytes.

Authors:  Nan Wang; Jun-Yan Li; Ting-Ting Zhao; Si-Ming Li; Cheng-Bin Shen; De-Shan Li; Wen-Fei Wang
Journal:  Inflammation       Date:  2018-02       Impact factor: 4.092

Review 3.  A Pathogenic Relationship of Bronchopulmonary Dysplasia and Retinopathy of Prematurity? A Review of Angiogenic Mediators in Both Diseases.

Authors:  Ashley Stark; Christiane Dammann; Heber C Nielsen; MaryAnn V Volpe
Journal:  Front Pediatr       Date:  2018-06-13       Impact factor: 3.418

Review 4.  The FGF metabolic axis.

Authors:  Xiaokun Li
Journal:  Front Med       Date:  2019-09-07       Impact factor: 4.592

5.  In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice.

Authors:  Frédéric Paré; Ginette Tardif; Hassan Fahmi; Yassine Ouhaddi; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Journal:  Aging (Albany NY)       Date:  2020-02-01       Impact factor: 5.682
  5 in total

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