Critical appraisal of studies using laboratory animal models.

In this manuscript we discuss an approach to critically appraising papers based on the results of laboratory animal experiments. The roles of external and internal validity in critically appraising the results of a paper are introduced. The risk of bias domains used by the Cochrane Handbook of Systematic Reviews of Interventions form the basis for assessing internal validity. The bias domains discussed include the selection bias, performance bias, outcome assessment bias, attrition bias, and reporting bias. Further, an approach to considering the role of chance in research findings is discussed.