| Literature DB >> 25541351 |
Soheila Hosseinzadeh1, Maryam Zahmatkesh2, Mansour Heidari3, Gholam-Reza Hassanzadeh4, Morteza Karimian5, Abdolfattah Sarrafnejad6, Mohammad-Reza Zarrindast1.
Abstract
The DHCR24 (24-dehydrocholesterol reductase) gene codes a multifunctional protein which consists of enzymatic, antioxidant, and anti-apoptotic activities. It exists in almost all neurons and protects the neural cells against amyloid β toxicity. Several studies have shown the down regulation of DHCR24 in Alzheimer's disease. We examined the time profile of DHCR24-mRNA alteration in an animal model of streptozotocin (STZ)-induced cognitive impairment. The DHCR24 mRNA levels of hippocampus and cognitive impairment were evaluated at 7, 14, and 21 days after intracerebroventricular (ICV)-STZ/Saline administration. DHCR24 expression was down regulated at 14 and 21 days after ICV-STZ administration. The decrease in expression of DHCR24 preceded the onset of the cognitive impairment. These results suggest the potential relation between DHCR24 expression and cognitive impairment.Entities:
Keywords: Alzheimer; DHCR24; Hippocampus; Streptozotocin
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Year: 2014 PMID： 25541351 DOI： 10.1016/j.neulet.2014.12.039
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046