Juan Morote1, Antonio Gómez-Caamaño2, José L Alvarez-Ossorio3, Daniel Pesqueira4, Angel Tabernero5, Francisco Gómez Veiga6, José A Lorente7, Mariano Porras8, Juan J Lobato9, María J Ribal10, Jacques Planas11. 1. Department of Urology, Hospital Vall d'Hebron and Universitat Autónoma de Barcelona, Barcelona, Spain. Electronic address: jmorote@vhebron.net. 2. Department of Radiation Oncology, Hospital Clínico Universitario Santiago de Compostela, A Coruña, Spain. 3. Department of Urology, Hospital Universitario Puerta del Mar, Cadiz, Spain. 4. Department of Urology, Hospital Universitario Povisa, Pontevedra, Spain. 5. Department of Urology, Hospital Universitario La Paz, Madrid, Spain. 6. Department of Urology, Hospital A Coruña, A Coruña, Spain. 7. Department of Urology, Hospital del Mar, Barcelona, Spain. 8. Department of Radiation Oncology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. 9. Department of Urology, Hospital General Universitario de Alicante, Alicante, Spain. 10. Department of Urology, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain. 11. Department of Urology, Hospital Vall d'Hebron and Universitat Autónoma de Barcelona, Barcelona, Spain.
Abstract
PURPOSE: Androgen deprivation therapy may promote the development of the metabolic syndrome in patients with prostate cancer. We assessed the prevalence of the full metabolic syndrome and its components during the first year of androgen deprivation therapy. MATERIALS AND METHODS: This observational, multicenter, prospective study included 539 patients with prostate cancer scheduled to receive 3-month depot luteinizing hormone-releasing hormone analogs for more than 12 months. Waist circumference, body mass index, lipid profile, blood pressure and fasting glucose were evaluated at baseline and after 6 and 12 months. The metabolic syndrome was assessed according to NCEP ATP III criteria (2001) and 4 other definitions (WHO 1998, AACE 2003, AHA/NHLBI 2005 and IDF 2005). RESULTS: At 6 and 12 months after the initiation of androgen deprivation therapy, significant increases were observed in waist circumference, body mass index, fasting glucose, triglycerides, total cholesterol, and high-density and low-density lipoprotein cholesterol. No significant changes in blood pressure 130/85 or greater were detected. A nonsignificant increase of 3.9% in the prevalence of the full metabolic syndrome (ATP III) was observed (22.9% at baseline vs 25.5% and 26.8% at 6 and 12 months, respectively). The prevalence of the metabolic syndrome at baseline varied according to the definition used, ranging from 9.4% (WHO) to 50% (IDF). At 12 months significant increases in prevalence were observed with the WHO (4.1%) and AHA/NHLBI (8.1%) definitions. CONCLUSIONS: Androgen deprivation therapy produces significant early effects on waist circumference, body mass index, fasting glucose, triglycerides and cholesterol. The prevalence of and increase in the metabolic syndrome depend on the defining criteria. Counseling patients on the prevention, early detection and treatment of specific metabolic alterations is recommended.
PURPOSE: Androgen deprivation therapy may promote the development of the metabolic syndrome in patients with prostate cancer. We assessed the prevalence of the full metabolic syndrome and its components during the first year of androgen deprivation therapy. MATERIALS AND METHODS: This observational, multicenter, prospective study included 539 patients with prostate cancer scheduled to receive 3-month depot luteinizing hormone-releasing hormone analogs for more than 12 months. Waist circumference, body mass index, lipid profile, blood pressure and fasting glucose were evaluated at baseline and after 6 and 12 months. The metabolic syndrome was assessed according to NCEP ATP III criteria (2001) and 4 other definitions (WHO 1998, AACE 2003, AHA/NHLBI 2005 and IDF 2005). RESULTS: At 6 and 12 months after the initiation of androgen deprivation therapy, significant increases were observed in waist circumference, body mass index, fasting glucose, triglycerides, total cholesterol, and high-density and low-density lipoprotein cholesterol. No significant changes in blood pressure 130/85 or greater were detected. A nonsignificant increase of 3.9% in the prevalence of the full metabolic syndrome (ATP III) was observed (22.9% at baseline vs 25.5% and 26.8% at 6 and 12 months, respectively). The prevalence of the metabolic syndrome at baseline varied according to the definition used, ranging from 9.4% (WHO) to 50% (IDF). At 12 months significant increases in prevalence were observed with the WHO (4.1%) and AHA/NHLBI (8.1%) definitions. CONCLUSIONS: Androgen deprivation therapy produces significant early effects on waist circumference, body mass index, fasting glucose, triglycerides and cholesterol. The prevalence of and increase in the metabolic syndrome depend on the defining criteria. Counseling patients on the prevention, early detection and treatment of specific metabolic alterations is recommended.
Authors: Kim Edmunds; Haitham Tuffaha; Daniel A Galvão; Paul Scuffham; Robert U Newton Journal: Support Care Cancer Date: 2020-01-07 Impact factor: 3.603
Authors: Ashley Bigaran; Eva Zopf; Jason Gardner; Andre La Gerche; Declan G Murphy; Erin J Howden; Michael K Baker; Prue Cormie Journal: Prostate Cancer Prostatic Dis Date: 2020-08-28 Impact factor: 5.554