Literature DB >> 2554125

Second messengers involved in the muscarinic control of the heart: the role of the phosphoinositide response.

J N Hawthorne1, S H Simmonds.   

Abstract

Two heart muscarinic responses are compared, the reduction of cyclic AMP concentration and the hydrolysis of phosphoinositides. It is suggested that the former is more important physiologically, since the latter is a slow response requiring much higher agonist concentrations. Inositol trisphosphate released from phosphoinositides is unlikely to produce a positive inotropic effect by releasing calcium from the sarcoplasmic reticulum. However, long term muscarinic effects may involve activation of protein kinase C by diacylglycerol released from phosphoinositides.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2554125     DOI： 10.1007/BF00220774

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  12 in total

1.  Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor.

Authors:  T Kubo; K Fukuda; A Mikami; A Maeda; H Takahashi; M Mishina; T Haga; K Haga; A Ichiyama; K Kangawa
Journal:  Nature       Date:  1986 Oct 2-8       Impact factor: 49.962

Review 2.  The role of protein kinase C in cell surface signal transduction and tumour promotion.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1984 Apr 19-25       Impact factor: 49.962

3.  Phosphorylation of cardiac sarcoplasmic reticulum by a calcium-activated, phospholipid-dependent protein kinase.

Authors:  C J Limas
Journal:  Biochem Biophys Res Commun       Date:  1980-10-16       Impact factor: 3.575

4.  Evidence for a carbachol stimulated phosphatidylinositol effect in heart.

Authors:  E E Quist
Journal:  Biochem Pharmacol       Date:  1982-10-01       Impact factor: 5.858

5.  Muscarinic stimulation of phosphatidylinositol metabolism in atria.

Authors:  S L Brown; J H Brown
Journal:  Mol Pharmacol       Date:  1983-11       Impact factor: 4.436

6.  Inositol trisphosphate does not release Ca2+ from permeabilized cardiac myocytes and sarcoplasmic reticulum.

Authors:  M A Movsesian; A P Thomas; M Selak; J R Williamson
Journal:  FEBS Lett       Date:  1985-06-17       Impact factor: 4.124

7.  Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.

Authors:  M Hirata; E Suematsu; T Hashimoto; T Hamachi; T Koga
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

8.  Identification of an endogenous protein kinase C activity and its intrinsic 15-kilodalton substrate in purified canine cardiac sarcolemmal vesicles.

Authors:  C F Presti; B T Scott; L R Jones
Journal:  J Biol Chem       Date:  1985-11-05       Impact factor: 5.157

9.  Phorbol ester- and diacylglycerol-mediated desensitization of cardiac beta-adrenergic receptors.

Authors:  C J Limas; C Limas
Journal:  Circ Res       Date:  1985-09       Impact factor: 17.367

10.  Positive inotropic effects induced by carbachol in rat atria treated with islet-activating protein (IAP)--association with phosphatidylinositol breakdown.

Authors:  S Imai; H Ohta
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.