Literature DB >> 25541140

TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.

Kira Rubtsova1, Philippa Marrack2, Anatoly V Rubtsov3.   

Abstract

The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFNγ) in the development of autoimmunity. We will also review recent data indicating how these factors may affect an immune response in a gender-dependent manner.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ABCs; Autoimmunity; Gender; IFNgamma; T-bet; TLR7

Mesh：

Substances：

Year:  2014        PMID： 25541140      PMCID： PMC4380581          DOI： 10.1016/j.cellimm.2014.12.002

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  48 in total

1.  IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice.

Authors:  C Haas; B Ryffel; M Le Hir
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

2.  Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

Authors:  D Balomenos; R Rumold; A N Theofilopoulos
Journal:  J Clin Invest       Date:  1998-01-15       Impact factor: 14.808

Review 3.  Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity.

Authors:  M Cutolo; A Sulli; S Capellino; B Villaggio; P Montagna; B Seriolo; R H Straub
Journal:  Lupus       Date:  2004       Impact factor: 2.911

4.  Sex-determined susceptibility and differential IFN-gamma and TNF-alpha mRNA expression in DBA/2 mice infected with Leishmania mexicana.

Authors:  A Satoskar; J Alexander
Journal:  Immunology       Date:  1995-01       Impact factor: 7.397

5.  T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.

Authors:  Jonathan H Esensten; Michael R Lee; Laurie H Glimcher; Jeffrey A Bluestone
Journal:  J Immunol       Date:  2009-06-17       Impact factor: 5.422

6.  T-box transcription-factor-deficient mice display increased joint pathology and failure of infection control during staphylococcal arthritis.

Authors:  Olof H Hultgren; Margareta Verdrengh; Andrej Tarkowski
Journal:  Microbes Infect       Date:  2004-05       Impact factor: 2.700

7.  Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis.

Authors:  J P Seery; J M Carroll; V Cattell; F M Watt
Journal:  J Exp Med       Date:  1997-11-03       Impact factor: 14.307

8.  In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

Authors:  C O Jacob; P H van der Meide; H O McDevitt
Journal:  J Exp Med       Date:  1987-09-01       Impact factor: 14.307

9.  The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

Authors:  Timothy R D J Radstake; Lenny van Bon; Jasper Broen; Anila Hussiani; Roger Hesselstrand; Dirk M Wuttge; Yanhui Deng; Robbert Simms; Erik Lubberts; Robert Lafyatis
Journal:  PLoS One       Date:  2009-06-17       Impact factor: 3.240

10.  Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.

Authors:  Estelle Bettelli; Brandon Sullivan; Susanne J Szabo; Raymond A Sobel; Laurie H Glimcher; Vijay K Kuchroo
Journal:  J Exp Med       Date:  2004-07-05       Impact factor: 14.307
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  18 in total

1.  Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia.

Authors:  Jincheng Yang; Kun Chen; Bin Wang; Liudi Wang; Shuya Qi; Weihua Wang
Journal:  Invest New Drugs       Date:  2019-07-04       Impact factor: 3.850

Review 2.  The role of sex in uveitis and ocular inflammation.

Authors:  Ian Y L Yeung; Nicholas A Popp; Chi-Chao Chan
Journal:  Int Ophthalmol Clin       Date:  2015

3.  The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.

Authors:  Heekyong R Bae; Deborah L Hodge; Guo-Xiang Yang; Patrick S C Leung; Sathi Babu Chodisetti; Julio C Valencia; Michael Sanford; John M Fenimore; Ziaur S M Rahman; Koichi Tsuneyama; Gary L Norman; M Eric Gershwin; Howard A Young
Journal:  Hepatology       Date:  2018-02-18       Impact factor: 17.425

4.  Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Authors:  Scott A Jenks; Kevin S Cashman; Esther Zumaquero; Urko M Marigorta; Aakash V Patel; Xiaoqian Wang; Deepak Tomar; Matthew C Woodruff; Zoe Simon; Regina Bugrovsky; Emily L Blalock; Christopher D Scharer; Christopher M Tipton; Chungwen Wei; S Sam Lim; Michelle Petri; Timothy B Niewold; Jennifer H Anolik; Greg Gibson; F Eun-Hyung Lee; Jeremy M Boss; Frances E Lund; Ignacio Sanz
Journal:  Immunity       Date:  2018-10-09       Impact factor: 31.745

5.  B cells expressing the transcription factor T-bet drive lupus-like autoimmunity.

Authors:  Kira Rubtsova; Anatoly V Rubtsov; Joshua M Thurman; Johanna M Mennona; John W Kappler; Philippa Marrack
Journal:  J Clin Invest       Date:  2017-02-27       Impact factor: 14.808

6.  Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus.

Authors:  Wenqian Zhang; Huihui Zhang; Shujun Liu; Fucan Xia; Zijian Kang; Yan Zhang; Yaoyang Liu; Hui Xiao; Lei Chen; Chuanxin Huang; Nan Shen; Huji Xu; Fubin Li
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-26       Impact factor: 11.205

Review 7.  B cell targeted therapies in autoimmune disease.

Authors:  Jennifer L Barnas; Richard John Looney; Jennifer H Anolik
Journal:  Curr Opin Immunol       Date:  2019-11-14       Impact factor: 7.486

Review 8.  Sexual dimorphism in autoimmunity.

Authors:  Kira Rubtsova; Philippa Marrack; Anatoly V Rubtsov
Journal:  J Clin Invest       Date:  2015-04-27       Impact factor: 14.808

9.  Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression.

Authors:  Samuel W Du; Tanvi Arkatkar; Holly M Jacobs; David J Rawlings; Shaun W Jackson
Journal:  Eur J Immunol       Date:  2018-11-05       Impact factor: 5.532

Review 10.  Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity.

Authors:  Yu-Qing Xie; Hong-Di Ma; Zhe-Xiong Lian
Journal:  Clin Rev Allergy Immunol       Date:  2016-06       Impact factor: 8.667
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