Literature DB >> 25540721

Neuropsychiatric genetics in developing countries: Current challenges.

Diego A Forero1, Alberto Vélez-van-Meerbeke1, Smita N Deshpande1, Humberto Nicolini1, George Perry1.   

Abstract

Neuropsychiatric disorders (NPDs) constitute a heavy burden on public health systems around the world and studies have demonstrated that the negative impact of NPDs is larger in Low and Middle Income Countries (LMICs). In recent decades, several studies have come to the understanding that genetic factors play a major role in the risk for a large number of NPDs. However, few neuropsychiatric genetics studies have been published from LMICs. In this Editorial, we discuss important issues impinging on advances in neuropsychiatric genetics research in LMICs. It is essential that scientists educate policymakers and officials of funding agencies on the importance of providing adequate funding for research in these areas. Development of local well-supported research programs focused on NPD genetics should be an important asset to develop; it would facilitate the establishment of sustainable research efforts that could lead to appropriate diagnosis and specific, affordable and feasible interventions in LMICs. It is important to point out that research into the biological basis of human NPDs is not only an academic effort reserved for a few elite institutions in economically developed countries, but it is vitally important for the mental health of people around the world.

Entities:  

Keywords:  Mental health; Neurogenetics; Neurosciences; Psychiatric genetics; Public health

Year:  2014        PMID: 25540721      PMCID: PMC4274588          DOI: 10.5498/wjp.v4.i4.69

Source DB:  PubMed          Journal:  World J Psychiatry        ISSN: 2220-3206


  24 in total

Review 1.  Neurology and psychiatry: closing the great divide.

Authors:  B H Price; R D Adams; J T Coyle
Journal:  Neurology       Date:  2000-01-11       Impact factor: 9.910

2.  Conducting psychiatric research in the developing world: challenges and rewards.

Authors:  Atalay Alem; Derege Kebede
Journal:  Br J Psychiatry       Date:  2003-03       Impact factor: 9.319

3.  Dementia in Latin America and the Caribbean: an overlooked epidemic.

Authors:  Gladys E Maestre
Journal:  Neuroepidemiology       Date:  2008-10-20       Impact factor: 3.282

4.  Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder.

Authors:  Taryn Castro; Heidi Eliana Mateus; Dora Janeth Fonseca; Diego Forero; Carlos Martín Restrepo; Claudia Talero; Alberto Vélez; Paul Laissue
Journal:  Neurol Sci       Date:  2013-11-01       Impact factor: 3.307

5.  A genome-wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32.

Authors:  Suzanne Gonzalez; Cynthia Camarillo; Marco Rodriguez; Mercedes Ramirez; Juan Zavala; Regina Armas; Salvador A Contreras; Javier Contreras; Albana Dassori; Laura Almasy; Deborah Flores; Alvaro Jerez; Henriette Raventós; Alfonso Ontiveros; Humberto Nicolini; Michael Escamilla
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2014-07-18       Impact factor: 3.568

6.  Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia.

Authors:  Diego A Forero; Bruno Benítez; Gonzalo Arboleda; Juan J Yunis; Rodrigo Pardo; Humberto Arboleda
Journal:  Neurosci Res       Date:  2006-05-15       Impact factor: 3.304

7.  A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects.

Authors:  Diego A Ojeda; Carmen L Niño; Sandra López-León; Andrés Camargo; Ana Adan; Diego A Forero
Journal:  J Neurol Sci       Date:  2013-12-11       Impact factor: 3.181

Review 8.  No health without mental health.

Authors:  Martin Prince; Vikram Patel; Shekhar Saxena; Mario Maj; Joanna Maselko; Michael R Phillips; Atif Rahman
Journal:  Lancet       Date:  2007-09-08       Impact factor: 79.321

9.  Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys.

Authors:  Koen Demyttenaere; Ronny Bruffaerts; Jose Posada-Villa; Isabelle Gasquet; Viviane Kovess; Jean Pierre Lepine; Matthias C Angermeyer; Sebastian Bernert; Giovanni de Girolamo; Pierluigi Morosini; Gabriella Polidori; Takehiko Kikkawa; Norito Kawakami; Yutaka Ono; Tadashi Takeshima; Hidenori Uda; Elie G Karam; John A Fayyad; Aimee N Karam; Zeina N Mneimneh; Maria Elena Medina-Mora; Guilherme Borges; Carmen Lara; Ron de Graaf; Johan Ormel; Oye Gureje; Yucun Shen; Yueqin Huang; Mingyuan Zhang; Jordi Alonso; Josep Maria Haro; Gemma Vilagut; Evelyn J Bromet; Semyon Gluzman; Charles Webb; Ronald C Kessler; Kathleen R Merikangas; James C Anthony; Michael R Von Korff; Philip S Wang; Traolach S Brugha; Sergio Aguilar-Gaxiola; Sing Lee; Steven Heeringa; Beth-Ellen Pennell; Alan M Zaslavsky; T Bedirhan Ustun; Somnath Chatterji
Journal:  JAMA       Date:  2004-06-02       Impact factor: 56.272

10.  The burden of complex genetics in brain disorders.

Authors:  George R Uhl; Robert W Grow
Journal:  Arch Gen Psychiatry       Date:  2004-03
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  6 in total

1.  Meta-analysis of Telomere Length in Alzheimer's Disease.

Authors:  Diego A Forero; Yeimy González-Giraldo; Catalina López-Quintero; Luis J Castro-Vega; George E Barreto; George Perry
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2016-04-18       Impact factor: 6.053

Review 2.  Autism genetics: opportunities and challenges for clinical translation.

Authors:  Jacob A S Vorstman; Jeremy R Parr; Daniel Moreno-De-Luca; Richard J L Anney; John I Nurnberger; Joachim F Hallmayer
Journal:  Nat Rev Genet       Date:  2017-03-06       Impact factor: 53.242

3.  Functional and Genomic Features of Human Genes Mutated in Neuropsychiatric Disorders.

Authors:  Diego A Forero; Carlos F Prada; George Perry
Journal:  Open Neurol J       Date:  2016-11-11

4.  The elusive ideal of inclusiveness: lessons from a worldwide survey of neurologists on the ethical issues raised by whole-genome sequencing.

Authors:  Thierry Hurlimann; Iris Jaitovich Groisman; Béatrice Godard
Journal:  BMC Med Ethics       Date:  2017-04-11       Impact factor: 2.652

5.  Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

Authors:  Tim B Bigdeli; Giulio Genovese; Michele T Pato; Steven A McCarroll; Carlos N Pato; Penelope Georgakopoulos; Jacquelyn L Meyers; Roseann E Peterson; Conrad O Iyegbe; Helena Medeiros; Jorge Valderrama; Eric D Achtyes; Roman Kotov; Eli A Stahl; Colony Abbott; Maria Helena Azevedo; Richard A Belliveau; Elizabeth Bevilacqua; Evelyn J Bromet; William Byerley; Celia Barreto Carvalho; Sinéad B Chapman; Lynn E DeLisi; Ashley L Dumont; Colm O'Dushlaine; Oleg V Evgrafov; Laura J Fochtmann; Diane Gage; James L Kennedy; Becky Kinkead; Antonio Macedo; Jennifer L Moran; Christopher P Morley; Mantosh J Dewan; James Nemesh; Diana O Perkins; Shaun M Purcell; Jeffrey J Rakofsky; Edward M Scolnick; Brooke M Sklar; Pamela Sklar; Jordan W Smoller; Patrick F Sullivan; Fabio Macciardi; Stephen R Marder; Ruben C Gur; Raquel E Gur; David L Braff; Humberto Nicolini; Michael A Escamilla; Marquis P Vawter; Janet L Sobell; Dolores Malaspina; Douglas S Lehrer; Peter F Buckley; Mark H Rapaport; James A Knowles; Ayman H Fanous
Journal:  Mol Psychiatry       Date:  2019-10-07       Impact factor: 15.992

6.  No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects.

Authors:  Yeimy González-Giraldo; Andrés Camargo; Sandra López-León; Diego A Forero
Journal:  Depress Res Treat       Date:  2015-10-08
  6 in total

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