Ruth Ann Marrie1, Lawrence Elliott2, James Marriott2, Michael Cossoy2, Aruni Tennakoon2, Nancy Yu2. 1. From the Departments of Internal Medicine (R.A.M., J.M., M.C., A.T., N.Y.) and Community Health Sciences (R.A.M., L.E.), University of Manitoba, Winnipeg, Canada. rmarrie@hsc.mb.ca. 2. From the Departments of Internal Medicine (R.A.M., J.M., M.C., A.T., N.Y.) and Community Health Sciences (R.A.M., L.E.), University of Manitoba, Winnipeg, Canada.
Abstract
OBJECTIVE: We aimed to evaluate the association between comorbidity and rates of hospitalization in the multiple sclerosis (MS) population as compared to a matched cohort from the general population. METHODS: Using population-based administrative data from the Canadian province of Manitoba, we identified 4,875 persons with MS and a matched general population cohort of 24,533 persons. We identified all acute care hospitalizations in the period 2007-2011. Using general linear models, we evaluated the association between comorbidity status and hospitalization rates (all-cause, non-MS-related, MS-related) in the 2 populations, adjusting for age, sex, and socioeconomic status. RESULTS: Comorbidity was common in both cohorts. Over the 5-year study period, the MS population had a 1.5-fold higher hospitalization rate (adjusted rate ratio [aRR] 1.56; 95% confidence interval [CI] 1.44-1.68) than the matched population. Any comorbidity was associated with a 2-fold increased risk of non-MS-related hospitalization rates (aRR 2.21; 95% CI 1.73-2.82) in the MS population, but a nearly 4-fold increase in hospitalization rates in the matched population (aRR 3.85; 95% CI 3.40-4.35). Comorbidity was not associated with rates of hospitalization for MS-related reasons, regardless of how comorbidity status was defined. CONCLUSIONS: In the MS population, comorbidity is associated with an increased risk of all-cause hospitalizations, suggesting that the prevention and management of comorbidity may reduce hospitalizations.
OBJECTIVE: We aimed to evaluate the association between comorbidity and rates of hospitalization in the multiple sclerosis (MS) population as compared to a matched cohort from the general population. METHODS: Using population-based administrative data from the Canadian province of Manitoba, we identified 4,875 persons with MS and a matched general population cohort of 24,533 persons. We identified all acute care hospitalizations in the period 2007-2011. Using general linear models, we evaluated the association between comorbidity status and hospitalization rates (all-cause, non-MS-related, MS-related) in the 2 populations, adjusting for age, sex, and socioeconomic status. RESULTS: Comorbidity was common in both cohorts. Over the 5-year study period, the MS population had a 1.5-fold higher hospitalization rate (adjusted rate ratio [aRR] 1.56; 95% confidence interval [CI] 1.44-1.68) than the matched population. Any comorbidity was associated with a 2-fold increased risk of non-MS-related hospitalization rates (aRR 2.21; 95% CI 1.73-2.82) in the MS population, but a nearly 4-fold increase in hospitalization rates in the matched population (aRR 3.85; 95% CI 3.40-4.35). Comorbidity was not associated with rates of hospitalization for MS-related reasons, regardless of how comorbidity status was defined. CONCLUSIONS: In the MS population, comorbidity is associated with an increased risk of all-cause hospitalizations, suggesting that the prevention and management of comorbidity may reduce hospitalizations.
Authors: Ruth Ann Marrie; Bo N Yu; Stella Leung; Lawrence Elliott; Patricia Caetano; Sharon Warren; Christina Wolfson; Scott B Patten; Lawrence W Svenson; Helen Tremlett; John Fisk; James F Blanchard Journal: Mult Scler Relat Disord Date: 2013-04-02 Impact factor: 4.339
Authors: Shivanand P Lad; Christopher H Chapman; Michael Vaninetti; Lawrence Steinman; Ari Green; Maxwell Boakye Journal: Neuroepidemiology Date: 2010-06-15 Impact factor: 3.282
Authors: Ruth Ann Marrie; Bo Nancy Yu; Stella Leung; Lawrence Elliott; Patricia Caetano; Sharon Warren; Christina Wolfson; Scott B Patten; Lawrence W Svenson; Helen Tremlett; John Fisk; James F Blanchard Journal: Neuroepidemiology Date: 2012-10-24 Impact factor: 3.282
Authors: Prudence Tettey; Steve Simpson; Bruce Taylor; Leigh Blizzard; Anne-Louise Ponsonby; Terence Dwyer; Karam Kostner; Ingrid van der Mei Journal: J Neurol Sci Date: 2014-03-05 Impact factor: 3.181
Authors: Ruth Ann Marrie; Lawrence Elliott; James Marriott; Michael Cossoy; James Blanchard; Aruni Tennakoon; Nancy Yu Journal: Neurology Date: 2014-08-01 Impact factor: 9.910
Authors: Kaarina Kowalec; Kyla A McKay; Scott B Patten; John D Fisk; Charity Evans; Helen Tremlett; Ruth Ann Marrie Journal: Neurology Date: 2017-11-08 Impact factor: 9.910
Authors: Gorica D Maric; Tatjana D Pekmezovic; Sarlota T Mesaros; Olivera S Tamas; Jovana B Ivanovic; Vanja N Martinovic; Marko M Andabaka; Aleksa Lj Jovanovic; Nikola D Veselinovic; Darija B Kisic-Tepavcevic; Jelena S Drulovic Journal: Neurol Sci Date: 2020-09-22 Impact factor: 3.307