Literature DB >> 25540212

A woman's experience of tapering from buprenorphine during pregnancy.

Gabrielle Katrine Welle-Strand1, Odd Kvamme2, Andreas Andreassen3, Edle Ravndal4.   

Abstract

Although opioid maintenance treatment (OMT) is the treatment of choice for pregnant opioid-dependent patients, some professionals argue that tapering the medication dose will reduce the severity of neonatal abstinence syndrome (NAS). This case description is based on the patient's detailed blog, and medical records from her general practitioner and the hospital. The patient is an employed, 32-year-old drug-abstinent woman in OMT. Her taper from 24 mg of buprenorphine started at 14 weeks' gestation and is slow, with withdrawal symptoms increasing gradually. In pregnancy week 31, she is off buprenorphine but she has severe withdrawal symptoms. She chose to go back on 4 mg of buprenorphine. The patient's son was born in pregnancy week 38+3, weighs 2950 g and does not require pharmacological treatment for NAS. The fetus most probably did experience fetal stress during the patient's tapering. It was the right decision by the patient to go back on buprenorphine. 2014 BMJ Publishing Group Ltd.

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Year:  2014        PMID: 25540212      PMCID: PMC4281552          DOI: 10.1136/bcr-2014-207207

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  14 in total

1.  Treating opioid use disorders during pregnancy: historical, current, and future directions.

Authors:  Hendrée E Jones
Journal:  Subst Abus       Date:  2013       Impact factor: 3.716

Review 2.  Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus?

Authors:  John J McCarthy
Journal:  J Matern Fetal Neonatal Med       Date:  2011-08-25

Review 3.  From opioid maintenance to abstinence: a literature review.

Authors:  Hege Kornør; Helge Waal
Journal:  Drug Alcohol Rev       Date:  2005-05

4.  Neonatal abstinence syndrome after methadone or buprenorphine exposure.

Authors:  Hendrée E Jones; Karol Kaltenbach; Sarah H Heil; Susan M Stine; Mara G Coyle; Amelia M Arria; Kevin E O'Grady; Peter Selby; Peter R Martin; Gabriele Fischer
Journal:  N Engl J Med       Date:  2010-12-09       Impact factor: 91.245

5.  Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009.

Authors:  Gabrielle K Welle-Strand; Svetlana Skurtveit; Hendreé E Jones; Helge Waal; Brittelise Bakstad; Lisa Bjarkø; Edle Ravndal
Journal:  Drug Alcohol Depend       Date:  2012-07-25       Impact factor: 4.492

6.  Opioid detoxification in pregnancy.

Authors:  J S Dashe; G L Jackson; D A Olscher; E H Zane; G D Wendel
Journal:  Obstet Gynecol       Date:  1998-11       Impact factor: 7.661

7.  Is opiate detoxification unsafe in pregnancy?

Authors:  Jason Luty; Vasilis Nikolaou; Jenny Bearn
Journal:  J Subst Abuse Treat       Date:  2003-06

8.  Dosing and monitoring of methadone in pregnancy: literature review.

Authors:  Jennifer R Shiu; Mary H H Ensom
Journal:  Can J Hosp Pharm       Date:  2012-09

Review 9.  The opioid-exposed newborn: assessment and pharmacologic management.

Authors:  Lauren M Jansson; Martha Velez; Cheryl Harrow
Journal:  J Opioid Manag       Date:  2009 Jan-Feb

10.  Methadone disposition during the perinatal period in humans.

Authors:  M J Kreek
Journal:  Pharmacol Biochem Behav       Date:  1979       Impact factor: 3.533

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  1 in total

1.  Management of eight labor and delivery patients dependent on buprenorphine (Subutex™): A retrospective chart review.

Authors:  Solina Tith; Garinder Bining; Laurent Bollag
Journal:  F1000Res       Date:  2018-01-03
  1 in total

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