Chengjun Yao1,2, Shunzeng Lv3, Hong Chen4, Weijun Tang5, Jun Guo6, Dongxiao Zhuang1,2, Nikos Chrisochoides7, Jinsong Wu1,2, Ying Mao2, Liangfu Zhou2. 1. a Glioma Surgery Division. 2. b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China. 3. c Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China. 4. d Department of Neuropathology. 5. e Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China. 6. f Neurological Surgery Department, First People's Hospital of Yancheng, Jiang Su Province, P. R. China. 7. g Department of Computer Science, Old Dominion University, Norfolk, VA, USA.
Abstract
PURPOSE: Our aim was to evaluate the diagnostic value of multimodal Magnetic Resonance (MR) Image in the stereotactic biopsy of cerebral gliomas, and investigate its implications. MATERIALS AND METHODS: Twenty-four patients with cerebral gliomas underwent (1)H Magnetic Resonance Spectroscopy ((1)H-MRS)- and intraoperative Magnetic Resonance Imaging (iMRI)-supported stereotactic biopsy, and 23 patients underwent only the preoperative MRI-guided biopsy. The diagnostic yield, morbidity and mortality rates were analyzed. In addition, 20 patients underwent subsequent tumor resection, thus the diagnostic accuracy of the biopsy was further evaluated. RESULTS: The diagnostic accuracies of biopsies evaluated by tumor resection in the trial groups were better than control groups (92.3% and 42.9%, respectively, p = 0.031). The diagnostic yield in the trial groups was better than the control groups, but the difference was not statistically significant (100% and 82.6%, respectively, p = 0.05). The morbidity and mortality rates were similar in both groups. CONCLUSIONS: Multimodal MR image-guided glioma biopsy is practical and valuable. This technique can increase the diagnostic accuracy in the stereotactic biopsy of cerebral gliomas. Besides, it is likely to increase the diagnostic yield but requires further validation.
PURPOSE: Our aim was to evaluate the diagnostic value of multimodal Magnetic Resonance (MR) Image in the stereotactic biopsy of cerebral gliomas, and investigate its implications. MATERIALS AND METHODS: Twenty-four patients with cerebral gliomas underwent (1)H Magnetic Resonance Spectroscopy ((1)H-MRS)- and intraoperative Magnetic Resonance Imaging (iMRI)-supported stereotactic biopsy, and 23 patients underwent only the preoperative MRI-guided biopsy. The diagnostic yield, morbidity and mortality rates were analyzed. In addition, 20 patients underwent subsequent tumor resection, thus the diagnostic accuracy of the biopsy was further evaluated. RESULTS: The diagnostic accuracies of biopsies evaluated by tumor resection in the trial groups were better than control groups (92.3% and 42.9%, respectively, p = 0.031). The diagnostic yield in the trial groups was better than the control groups, but the difference was not statistically significant (100% and 82.6%, respectively, p = 0.05). The morbidity and mortality rates were similar in both groups. CONCLUSIONS: Multimodal MR image-guided glioma biopsy is practical and valuable. This technique can increase the diagnostic accuracy in the stereotactic biopsy of cerebral gliomas. Besides, it is likely to increase the diagnostic yield but requires further validation.
Authors: Shanshan Jiang; Charles G Eberhart; Yi Zhang; Hye-Young Heo; Zhibo Wen; Lindsay Blair; Huamin Qin; Michael Lim; Alfredo Quinones-Hinojosa; Jon D Weingart; Peter B Barker; Martin G Pomper; John Laterra; Peter C M van Zijl; Jaishri O Blakeley; Jinyuan Zhou Journal: Eur J Cancer Date: 2017-07-10 Impact factor: 9.162
Authors: Adam Wittek; George Bourantas; Benjamin F Zwick; Grand Joldes; Lionel Esteban; Karol Miller Journal: PLoS One Date: 2020-12-22 Impact factor: 3.240