Literature DB >> 2553735

Herpes simplex-1 DNA polymerase. Identification of an intrinsic 5'----3' exonuclease with ribonuclease H activity.

J J Crute1, I R Lehman.   

Abstract

The herpes simplex virus-1 DNA polymerase is a heterodimer of Mr 190,000 which consists of the products of the UL30 (Pol) and UL42 genes. The 136-kilodalton Pol gene product contains an intrinsic ribonuclease H activity that specifically degrades RNA.DNA heteroduplexes or duplex DNA substrates in the 5'----3' direction. It can therefore catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during herpes DNA replication.

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Year:  1989        PMID： 2553735

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  58 in total

1.  Leading and lagging strand DNA synthesis in vitro by a reconstituted herpes simplex virus type 1 replisome.

Authors:  M Falkenberg; I R Lehman; P Elias
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

2.  Rep-dependent initiation of adeno-associated virus type 2 DNA replication by a herpes simplex virus type 1 replication complex in a reconstituted system.

Authors:  P Ward; M Falkenberg; P Elias; M Weitzman; R M Linden
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

3.  Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42.

Authors:  Murari Chaudhuri; Deborah S Parris
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

Review 4.  Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

5.  Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit.

Authors:  Arianna Loregian; Alessandro Case; Enrico Cancellotti; Carlo Valente; Howard S Marsden; Giorgio Palù
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

6.  Helicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity.

Authors:  D K Klinedinst; M D Challberg
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

7.  Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.

Authors:  F Focher; G Maga; A Bendiscioli; M Capobianco; F Colonna; A Garbesi; S Spadari
Journal:  Nucleic Acids Res       Date:  1995-08-11       Impact factor: 16.971

8.  Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction.

Authors:  H Berthomme; S J Monahan; D S Parris; B Jacquemont; A L Epstein
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

9.  Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

Authors:  P A Johnson; M G Best; T Friedmann; D S Parris
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

10.  Rescue of the adeno-associated virus genome from a plasmid vector: evidence for rescue by replication.

Authors:  Peter Ward; Per Elias; R Michael Linden
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103
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