| Literature DB >> 25535918 |
Emily Clough1, Erin Jimenez2, Yoo-Ah Kim3, Cale Whitworth4, Megan C Neville5, Leonie U Hempel1, Hania J Pavlou5, Zhen-Xia Chen1, David Sturgill1, Ryan K Dale1, Harold E Smith1, Teresa M Przytycka3, Stephen F Goodwin5, Mark Van Doren2, Brian Oliver1.
Abstract
Primary sex-determination "switches" evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind different targets, or how DSX proteins direct different outcomes in diverse tissues. We undertook genome-wide analyses to identify DSX targets using in vivo occupancy, binding site prediction, and evolutionary conservation. We find that DSX(F) and DSX(M) bind thousands of the same targets in multiple tissues in both sexes, yet these targets have sex- and tissue-specific functions. Interestingly, DSX targets show considerable overlap with targets identified for mouse DMRT1. DSX targets include transcription factors and signaling pathway components providing for direct and indirect regulation of sex-biased expression.Entities:
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Year: 2014 PMID： 25535918 PMCID： PMC4275658 DOI： 10.1016/j.devcel.2014.11.021
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270