Literature DB >> 2553543

Antioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process.

A L Zanocco1, R Pavez, L A Videla, E A Lissi.   

Abstract

2,2'-Azobis-[2-amidinopropane] initiated lipid peroxidation of egg yolk phosphatydil choline liposomes was measured by oxygen uptake and the emitted visible luminescence. Lipid peroxidation involved a chain process (kinetic chain length = 49 +/- 11) and its rate was independent of added Fe ions. Diethyldithiocarbamate (DDC) behaved as an efficient inhibitor in the microM range, being able to trap 1.05 +/- 0.25 free radicals per added molecule. The efficiency of DDC was also independent of Fe addition to the system. These results indicate that DDC is able to trap the chain carrying free radicals, showing that this compound, besides being a powerful metal chelator, is also an efficient free radical scavenger. It is proposed that the relevant step in this process involves an electron transfer from DDC to the peroxy radical LOO., LOO. + DDC- ----LOO- + DDC. followed by protonation of LOO- and dimerization of the DDC. radical.

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Year:  1989        PMID： 2553543     DOI： 10.1016/0891-5849(89)90006-3

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  8 in total

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Authors:  A C Wild; R T Mulcahy
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Review 3.  Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity.

Authors:  Maricela Viola-Rhenals; Kush R Patel; Laura Jaimes-Santamaria; Guojun Wu; Jinbao Liu; Q Ping Dou
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4.  UV-B-Induced PR-1 Accumulation Is Mediated by Active Oxygen Species.

Authors:  R. Green; R. Fluhr
Journal:  Plant Cell       Date:  1995-02       Impact factor: 11.277

5.  Oxidative stress and sodium methyldithiocarbamate-induced modulation of the macrophage response to lipopolysaccharide in vivo.

Authors:  Stephen B Pruett; Bing Cheng; Ruping Fan; Wei Tan; Thomas Sebastian
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Authors:  Kristen C Kelley; Kenneth F Grossman; Mary Brittain-Blankenship; Kelli M Thorne; Wallace L Akerley; Moises C Terrazas; Ken M Kosak; Kenneth M Boucher; Saundra S Buys; Kimberly A McGregor; Theresa L Werner; Neeraj Agarwal; John R Weis; Sunil Sharma; John H Ward; Thomas P Kennedy; Douglas W Sborov; Paul J Shami
Journal:  BMC Cancer       Date:  2021-05-07       Impact factor: 4.430

7.  The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis.

Authors:  I Rahden-Staroń; E Grosicka-Maciąg; D Kurpios-Piec; H Czeczot; T Grzela; M Szumiło
Journal:  Arch Toxicol       Date:  2012-08-08       Impact factor: 5.153

8.  H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

Authors:  M Meyer; R Schreck; P A Baeuerle
Journal:  EMBO J       Date:  1993-05       Impact factor: 11.598
  8 in total

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