OBJECTIVE: To evaluate the relationship between blood glucose fluctuation and macrovascular dysfunction. PATIENTS AND METHODS: Eighty-eight type 2 diabetes mellitus (T2DM) patients with or without coronary heart disease (CHD) and 30 healthy control subjects were recruited. Glycosylated hemoglobin A1c (HbA1c), fasting insulin (FIns), and C-reaction protein (CRP) and some other general clinical variables were measured. A 72-hour continuous glucose monitoring (CGM) and brachial artery endothelium-dependent flow-mediated dilation (FMD) assessment were performed. The glucose excursion, MAGE (mean amplitude of glycemic excursions), LAGE (largest amplitude of glycemic excursions), MPPGE (mean postprandial glycemic excursions), MODD (absolute means of daily differences), and IAUC70 (incremental area under the curve below 70 mg/dl) during the CGM were analyzed. Correlations between the various variables were analyzed. RESULTS: Enhanced blood glucose fluctuation was observed in T2DM patients with CHD as compared to other participants. And blood glucose fluctuation was correlated with FMD, CRP and HOMA-IR. CONCLUSIONS: Blood glucose fluctuation is an important factor that affects inflammatory response and possibly induces CHD in T2DM patients.
OBJECTIVE: To evaluate the relationship between blood glucose fluctuation and macrovascular dysfunction. PATIENTS AND METHODS: Eighty-eight type 2 diabetes mellitus (T2DM) patients with or without coronary heart disease (CHD) and 30 healthy control subjects were recruited. Glycosylated hemoglobin A1c (HbA1c), fasting insulin (FIns), and C-reaction protein (CRP) and some other general clinical variables were measured. A 72-hour continuous glucose monitoring (CGM) and brachial artery endothelium-dependent flow-mediated dilation (FMD) assessment were performed. The glucose excursion, MAGE (mean amplitude of glycemic excursions), LAGE (largest amplitude of glycemic excursions), MPPGE (mean postprandial glycemic excursions), MODD (absolute means of daily differences), and IAUC70 (incremental area under the curve below 70 mg/dl) during the CGM were analyzed. Correlations between the various variables were analyzed. RESULTS: Enhanced blood glucose fluctuation was observed in T2DM patients with CHD as compared to other participants. And blood glucose fluctuation was correlated with FMD, CRP and HOMA-IR. CONCLUSIONS:Blood glucose fluctuation is an important factor that affects inflammatory response and possibly induces CHD in T2DM patients.
Authors: F Boscari; M D'Anna; B M Bonora; S Tresso; R Cappellari; A Avogaro; D Bruttomesso; G P Fadini Journal: J Endocrinol Invest Date: 2020-05-04 Impact factor: 4.256
Authors: Da Young Lee; Kyungdo Han; Sanghyun Park; Ji Hee Yu; Ji A Seo; Nam Hoon Kim; Hye Jin Yoo; Sin Gon Kim; Kyung Mook Choi; Sei Hyun Baik; Yong Gyu Park; Nan Hee Kim Journal: Cardiovasc Diabetol Date: 2020-09-22 Impact factor: 9.951