Karin Stiasny-Kolster1, Friederike Sixel-Döring2, Claudia Trenkwalder3, Monika Heinzel-Gutenbrunner4, Klaus Seppi5, Werner Poewe5, Birgit Högl5, Birgit Frauscher6. 1. Somnomar, Institute for Medical Research and Sleep Medicine, Marburg, Germany; Philipps-University, Marburg, Germany. 2. Paracelsus-Elena Klinik, Kassel, Germany. 3. Paracelsus-Elena Klinik, Kassel, Germany; University of Goettingen, Goettingen, Germany. 4. Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany. 5. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. 6. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: birgit.frauscher@i-med.ac.at.
Abstract
OBJECTIVE: We aimed to validate the rapid eye movement (REM) sleep behavior disorder (RBD) screening questionnaire (RBDSQ) in 2 independent samples of patients with Parkinson's disease (PD) using different settings when performing the investigations. METHODS: The RBDSQ was administered to two independent samples of 52 and 75 consecutive PD patients investigated with video-polysomnography (vPSG). RESULTS: In sample A, the RBDSQ identified 46/52 (88.5%) patients correctly. In sample B, 50/75 (66.7%) patients were identified correctly. Considering a cut-off score of ≥ 5 as a positive test result, sample A showed a sensitivity of 0.90 and a specificity of 0.87, sample B showed a sensitivity of 0.68 and a specificity of 0.63. Main differences between both groups were that patients of sample A underwent a sleep history including RBD assessment prior to administration of the RBDSQ, whereas in sample B the RBDSQ was administered during routine work-up. CONCLUSIONS: The diagnostic value of the RBDSQ strongly depends on the clinical setting and may be influenced by the individual's awareness on RBD. This finding is a critical issue which deserves clarification before use of this and other questionnaires can be recommended in epidemiological studies.
OBJECTIVE: We aimed to validate the rapid eye movement (REM) sleep behavior disorder (RBD) screening questionnaire (RBDSQ) in 2 independent samples of patients with Parkinson's disease (PD) using different settings when performing the investigations. METHODS: The RBDSQ was administered to two independent samples of 52 and 75 consecutive PDpatients investigated with video-polysomnography (vPSG). RESULTS: In sample A, the RBDSQ identified 46/52 (88.5%) patients correctly. In sample B, 50/75 (66.7%) patients were identified correctly. Considering a cut-off score of ≥ 5 as a positive test result, sample A showed a sensitivity of 0.90 and a specificity of 0.87, sample B showed a sensitivity of 0.68 and a specificity of 0.63. Main differences between both groups were that patients of sample A underwent a sleep history including RBD assessment prior to administration of the RBDSQ, whereas in sample B the RBDSQ was administered during routine work-up. CONCLUSIONS: The diagnostic value of the RBDSQ strongly depends on the clinical setting and may be influenced by the individual's awareness on RBD. This finding is a critical issue which deserves clarification before use of this and other questionnaires can be recommended in epidemiological studies.
Authors: Rachel Saunders-Pullman; Roy N Alcalay; Anat Mirelman; Cuiling Wang; Marta San Luciano; Roberto A Ortega; Amanda Glickman; Deborah Raymond; Helen Mejia-Santana; Nancy Doan; Brooke Johannes; Kira Yasinovsky; Laurie Ozelius; Lorraine Clark; Avi Orr-Utreger; Karen Marder; Nir Giladi; Susan B Bressman Journal: Mov Disord Date: 2015-09-14 Impact factor: 10.338