OBJECTIVE: To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. METHODS: A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. RESULTS: Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. SIGNIFICANCE: Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state. Wiley Periodicals, Inc.
OBJECTIVE: To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. METHODS: A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. RESULTS:Humanneurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. SIGNIFICANCE: Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state. Wiley Periodicals, Inc.
Authors: Marino M Bianchin; Tonicarlo R Velasco; Lauro Wichert-Ana; Osvaldo M Takayanagui; João P Leite; Américo C Sakamoto Journal: Epilepsia Date: 2010-11 Impact factor: 5.864
Authors: Winnie W Ooi; Subhashie Wijemanne; Christine B Thomas; Martha Quezado; Charles R Brown; Theodore E Nash Journal: Am J Trop Med Hyg Date: 2011-09 Impact factor: 2.345
Authors: Theodore E Nash; Luther A Bartelt; Poonum S Korpe; Beatriz Lopes; Eric R Houpt Journal: Am J Trop Med Hyg Date: 2014-01-06 Impact factor: 2.345
Authors: Theodore E Nash; E Javier Pretell; Andres G Lescano; Javier A Bustos; Robert H Gilman; Armando E Gonzalez; Héctor H Garcia Journal: Lancet Neurol Date: 2008-11-03 Impact factor: 44.182
Authors: Annamaria Vezzani; Robert S Fujinami; H Steve White; Pierre-Marie Preux; Ingmar Blümcke; Josemir W Sander; Wolfgang Löscher Journal: Acta Neuropathol Date: 2015-09-30 Impact factor: 17.088
Authors: Jay S Hanas; James R Hocker; Govindan Ramajayam; Vasudevan Prabhakaran; Vedantam Rajshekhar; Anna Oommen; Josephine J Manoj; Michael P Anderson; Douglas A Drevets; Hélène Carabin Journal: Exp Parasitol Date: 2018-08-08 Impact factor: 2.011
Authors: Vinod K Pilli; Michael E Behen; Jiani Hu; Yang Xuan; James Janisse; Harry T Chugani; Csaba Juhász Journal: Dev Med Child Neurol Date: 2017-04-11 Impact factor: 5.449
Authors: Oscar H Del Brutto; Gianfranco Arroyo; Victor J Del Brutto; Mauricio Zambrano; Héctor H García Journal: Epilepsia Date: 2017-08-29 Impact factor: 5.864