Literature DB >> 2553451

[3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung.

G Dent1, D Ukena, G W Sybrecht, P J Barnes.   

Abstract

The radiolabelled platelet activating factor (PAF) receptor antagonist, [3H]WEB 2086, bound to specific sites on membrane fractions from homogenised guinea pig and human lungs. The sites on guinea pig and human membranes bound [3H]WEB 2086 with dissociation constants (KD) of 16.8 and 22.6 nM and binding capacities (Bmax) of 203 and 157 fmol/mg protein, respectively. In both species, binding was displaced competitively by PAF, suggesting that the sites labelled by [3H]WEB 2086 are PAF receptors.

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Year:  1989        PMID： 2553451     DOI： 10.1016/0014-2999(89)90029-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

Review 1.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

2.  Effect of platelet activating factor on formation and composition of airway fluid in the guinea-pig trachea.

Authors:  D F Rogers; E W Alton; B Aursudkij; P Boschetto; A Dewar; P J Barnes
Journal:  J Physiol       Date:  1990-12       Impact factor: 5.182

3.  Platelet-activating factor stimulates eicosanoid production in cultured feline tracheal epithelial cells.

Authors:  T Wu; R D Rieves; C Logun; J H Shelhamer
Journal:  Lung       Date:  1995       Impact factor: 2.584

4.  Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins.

Authors:  S A Carlson; B D Jones
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441
  4 in total

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