José M de Miguel-Yanes1, Concepción Gonzalo-Hernando2, Nuria Muñoz-Rivas3, Manuel Méndez-Bailón4, Fernando Cava-Valenciano5, Juan Torres-Macho6. 1. Internal Medicine Department, Hospital Universitario Sureste, 10, Ronda del Sur, Arganda del Rey, 28500 Madrid, Spain. Electronic address: josemaria.demiguel@salud.madrid.org. 2. Internal Medicine Department, Hospital Universitario Henares, Avenida Marie Curie, s/n, Coslada, 28822 Madrid, Spain. 3. Internal Medicine Department, Hospital Universitario Infanta Leonor, 80, Avenida Gran Vía del Este, 28031 Madrid, Spain. 4. Internal Medicine Department, Hospital Clínico Universitario San Carlos, Profesor Martín Lagos, s/n, 28040 Madrid, Spain. 5. Laboratorio Unilabs, Hospital Universitario Reina Sofía, 34, Paseo de Europa, San Sebastián de los Reyes, 28702 Madrid, Spain. 6. Emergency Department, Hospital Universitario Infanta Cristina, 2, Avenida 9 de Junio, Parla, 28981 Madrid, Spain.
Abstract
BACKGROUND: We used data from three <250-bed hospitals to test how plasma glucose (PG) values influenced in-hospital mortality (IHM) in acute heart failure in people without diabetes. METHODS AND RESULTS: We identified 788 HF admissions (62% female; median age 83.3 years). 20.9% had chronic kidney disease, 7.7% cancer history, 24.7% acute renal failure and 29.7% concomitant infection. Mean first PG was 124.3 ± 32.4 mg/dl; 22.7% had stress hyperglycemia. Fifty-six people died (IHM = 7.1%). Women, older patients and people with infections showed higher PG values. People who died had higher PG values (136.3 ± 43.9 vs. 123.4 ± 31.2 mg/dl; p = 0.029). In a multivariate regression model with IHM as main outcome, the first PG (per mg/dl, odds ratio (OR): 1.01 [1.00-1.02]; p = 0.045), age (per year, OR: 1.06 [1.02-1.10]; p = 0.003) and acute renal failure (OR: 0.42 [0.24-0.74]; p = 0.003) remained significantly associated with IHM. CONCLUSIONS: The first PG value predicted IHM in participants without diabetes after admission for heart failure.
BACKGROUND: We used data from three <250-bed hospitals to test how plasma glucose (PG) values influenced in-hospital mortality (IHM) in acute heart failure in people without diabetes. METHODS AND RESULTS: We identified 788 HF admissions (62% female; median age 83.3 years). 20.9% had chronic kidney disease, 7.7% cancer history, 24.7% acute renal failure and 29.7% concomitant infection. Mean first PG was 124.3 ± 32.4 mg/dl; 22.7% had stress hyperglycemia. Fifty-six people died (IHM = 7.1%). Women, older patients and people with infections showed higher PG values. People who died had higher PG values (136.3 ± 43.9 vs. 123.4 ± 31.2 mg/dl; p = 0.029). In a multivariate regression model with IHM as main outcome, the first PG (per mg/dl, odds ratio (OR): 1.01 [1.00-1.02]; p = 0.045), age (per year, OR: 1.06 [1.02-1.10]; p = 0.003) and acute renal failure (OR: 0.42 [0.24-0.74]; p = 0.003) remained significantly associated with IHM. CONCLUSIONS: The first PG value predicted IHM in participants without diabetes after admission for heart failure.