Literature DB >> 25533458

A love affair with Bacillus subtilis.

Richard Losick1.   

Abstract

My career in science was launched when I was an undergraduate at Princeton University and reinforced by graduate training at the Massachusetts Institute of Technology. However, it was only after I moved to Harvard University as a junior fellow that my affections were captured by a seemingly mundane soil bacterium. What Bacillus subtilis offered was endless fascinating biological problems (alternative sigma factors, sporulation, swarming, biofilm formation, stochastic cell fate switching) embedded in a uniquely powerful genetic system. Along the way, my career in science became inseparably interwoven with teaching and mentoring, which proved to be as rewarding as the thrill of discovery.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Bacillus; Biofilm; Differentiation; RNA Polymerase; Sporulation

Mesh:

Substances:

Year:  2014        PMID: 25533458      PMCID: PMC4317029          DOI: 10.1074/jbc.X114.634808

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  103 in total

1.  Control of developmental transcription factor sigma F by sporulation regulatory proteins SpoIIAA and SpoIIAB in Bacillus subtilis.

Authors:  R Schmidt; P Margolis; L Duncan; R Coppolecchia; C P Moran; R Losick
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Characterization of bofA, a gene involved in intercompartmental regulation of pro-sigma K processing during sporulation in Bacillus subtilis.

Authors:  E Ricca; S Cutting; R Losick
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

Review 3.  Generating and exploiting polarity in bacteria.

Authors:  Lucy Shapiro; Harley H McAdams; Richard Losick
Journal:  Science       Date:  2002-12-06       Impact factor: 47.728

4.  Extracellular signal protein triggering the proteolytic activation of a developmental transcription factor in B. subtilis.

Authors:  A E Hofmeister; A Londoño-Vallejo; E Harry; P Stragier; R Losick
Journal:  Cell       Date:  1995-10-20       Impact factor: 41.582

5.  The genetics of bacteriophage SPO1.

Authors:  S Okubo; T Yanagida; D J Fujita; B M Olsson-Wilhelm
Journal:  Biken J       Date:  1972-06

6.  Gene encoding the 37,000-dalton minor sigma factor of Bacillus subtilis RNA polymerase: isolation, nucleotide sequence, chromosomal locus, and cryptic function.

Authors:  M L Duncan; S S Kalman; S M Thomas; C W Price
Journal:  J Bacteriol       Date:  1987-02       Impact factor: 3.490

7.  Regulation of a promoter that is utilized by minor forms of RNA polymerase holoenzyme in Bacillus subtilis.

Authors:  M M Igo; R Losick
Journal:  J Mol Biol       Date:  1986-10-20       Impact factor: 5.469

8.  The program of protein synthesis during sporulation in Bacillus subtilis.

Authors:  T Linn; R Losick
Journal:  Cell       Date:  1976-05       Impact factor: 41.582

Review 9.  Crisscross regulation of cell-type-specific gene expression during development in B. subtilis.

Authors:  R Losick; P Stragier
Journal:  Nature       Date:  1992-02-13       Impact factor: 49.962

10.  Genes involved in formation of structured multicellular communities by Bacillus subtilis.

Authors:  Steven S Branda; José Eduardo González-Pastor; Etienne Dervyn; S Dusko Ehrlich; Richard Losick; Roberto Kolter
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490

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  2 in total

1.  Regulation of Biofilm Aging and Dispersal in Bacillus subtilis by the Alternative Sigma Factor SigB.

Authors:  M Bartolini; S Cogliati; D Vileta; C Bauman; L Rateni; C Leñini; F Argañaraz; M Francisco; J M Villalba; L Steil; U Völker; R Grau
Journal:  J Bacteriol       Date:  2018-12-20       Impact factor: 3.490

2.  Stress-Responsive Alternative Sigma Factor SigB Plays a Positive Role in the Antifungal Proficiency of Bacillus subtilis.

Authors:  M Bartolini; S Cogliati; D Vileta; C Bauman; W Ramirez; R Grau
Journal:  Appl Environ Microbiol       Date:  2019-04-18       Impact factor: 4.792

  2 in total

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