Literature DB >> 25532953

Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review).

Asghar Ghasemi1, S Khalifi2, S Jedi1.   

Abstract

Diabetes is one of the five leading causes of death in the world, with type 2 diabetes occurring more frequently than type 1. Management of diabetes without side effects is still a challenge and therefore new strategies need to be examined. Because of difficulties in human research, animal models of diabetes are useful research tools for this purpose and rodent models of type 2 diabetes are the first choice. The aim of this study is an overview on one of the most frequently used models of type 2 diabetes in rat, induced by streptozotocin and nicotinamide, considering its advantages and disadvantages for diabetes research in humans.

Entities:  

Keywords:  animal model; nicotinamide; rat; streptozotocin; type 2 diabetes

Mesh：

Substances：

Year:  2014        PMID： 25532953     DOI： 10.1556/APhysiol.101.2014.4.2

Source DB:  PubMed          Journal:  Acta Physiol Hung        ISSN： 0231-424X


  39 in total

1.  Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy.

Authors:  Passant E Moustafa; Noha F Abdelkader; Sally A El Awdan; Osama A El-Shabrawy; Hala F Zaki
Journal:  Inflammation       Date:  2018-08       Impact factor: 4.092

2.  Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats.

Authors:  Fatma Kubra Tombulturk; Zeynep Gizem Todurga-Seven; Onder Huseyinbas; Sibel Ozyazgan; Turgut Ulutin; Gonul Kanigur-Sultuybek
Journal:  Mol Biol Rep       Date:  2021-10-31       Impact factor: 2.316

3.  Amelioration of diabetes and its complications by Manilkara zapota (L) P. Royen fruit peel extract and its fractions in alloxan and STZ-NA induced diabetes in Wistar rats.

Authors:  Pravin P Karle; Shashikant C Dhawale; Vijay V Navghare
Journal:  J Diabetes Metab Disord       Date:  2022-02-04

4.  The Attenuating Effect of Beta-Carotene on Streptozotocin Induced Diabetic Vascular Dementia Symptoms in Rats.

Authors:  Khian Giap Lim; Rajavel Varatharajan; Arunachalam Muthuraman
Journal:  Molecules       Date:  2022-07-04       Impact factor: 4.927

5.  Comparison of area under the curve in various models of diabetic rats receiving chronic medication.

Authors:  Keng-Fan Liu; Chiang-Shan Niu; Jen-Chieh Tsai; Chao-Lin Yang; Wen-Huang Peng; Ho-Shan Niu
Journal:  Arch Med Sci       Date:  2020-01-07       Impact factor: 3.707

6.  Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats.

Authors:  Alaa M Ali; Mohamed Abdel Gabbar; Sanaa M Abdel-Twab; Eman M Fahmy; Hossam Ebaid; Ibrahim M Alhazza; Osama M Ahmed
Journal:  Oxid Med Cell Longev       Date:  2020-06-20       Impact factor: 6.543

7.  Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin.

Authors:  Navid Neyshaburinezhad; Maryam Seidabadi; Mohammadreza Rouini; Hoda Lavasani; Alireza Foroumadi; Yalda H Ardakani
Journal:  Daru       Date:  2020-05-06       Impact factor: 3.117

Review 8.  New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR.

Authors:  Kenneth Maiese
Journal:  Front Biosci (Landmark Ed)       Date:  2020-06-01

Review 9.  Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity.

Authors:  Jinzi Wu; Liang-Jun Yan
Journal:  Diabetes Metab Syndr Obes       Date:  2015-04-02       Impact factor: 3.168

Review 10.  Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders.

Authors:  Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2021       Impact factor: 1.990
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