Literature DB >> 25532693

Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei.

Natasha L Williams1, Jodie L Morris2, Catherine M Rush2, Natkunam Ketheesan2.   

Abstract

Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.
Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Burkholderia pseudomallei; Dendritic cells; Interferon-alpha; Interferon-beta; Melioidosis

Mesh：

Substances：

Year:  2014        PMID： 25532693     DOI： 10.1016/j.micinf.2014.12.007

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  5 in total

1.  Diabetes alters immune response patterns to acute melioidosis in humans.

Authors:  Barbara Kronsteiner; Panjaporn Chaichana; Manutsanun Sumonwiriya; Kemajitra Jenjaroen; Fazle Rabbi Chowdhury; Suchintana Chumseng; Prapit Teparrukkul; Direk Limmathurotsakul; Nicholas P J Day; Paul Klenerman; Susanna J Dunachie
Journal:  Eur J Immunol       Date:  2019-05-08       Impact factor: 6.688

Review 2.  An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?

Authors:  Chalita Chomkatekaew; Phumrapee Boonklang; Apiwat Sangphukieo; Claire Chewapreecha
Journal:  Front Microbiol       Date:  2021-01-21       Impact factor: 5.640

3.  In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei.

Authors:  Durga Reddi; Lydia Durant; David Bernardo; Alistair Noble; Nicholas R English; Philip Hendy; Graeme C Clark; Joann L Prior; Ethel Diane Williamson; Stella C Knight
Journal:  Vaccines (Basel)       Date:  2021-08-22

4.  Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice.

Authors:  Rosemary A Hoffman; Sulan Huang; Geetha Chalasani; Abbe N Vallejo
Journal:  Aging Dis       Date:  2021-08-01       Impact factor: 6.745

5.  Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis.

Authors:  Kailyn L Stefan; Avner Fink; Neeraj K Surana; Dennis L Kasper; Suryasarathi Dasgupta
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240
  5 in total

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