Literature DB >> 25532473

The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review.

Tomoya Shiro1, Takayuki Fukaya1, Masanori Tobe2.   

Abstract

Among all heterocycles, the heterocycle-fused quinolinone scaffold is one of the privileged structures in drug discovery as heterocycle-fused quinolinone derivatives exhibit various biological activities allowing them to act as anti-inflammatory, anticancer, antidiabetic, and antipsychotic agents. This wide spectrum of biological activity has attracted a great deal of attention in the field of medicinal chemistry. In this review, we provide a comprehensive description of the biological and pharmacological properties of various heterocycle-fused quinolinone scaffolds and discuss the synthetic methods of some of their derivatives.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Heterocycles; Quinolin-4-one; Quinolinone

Mesh：

Substances：

Year:  2014        PMID： 25532473     DOI： 10.1016/j.ejmech.2014.12.004

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  14 in total

1.  Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress.

Authors:  Alok Tanala Patra; Tejashri Hingamire; Meenakshi A Belekar; Aoli Xiong; Gowtham Subramanian; Zbynek Bozdech; Peter Preiser; Dhanasekaran Shanmugam; Rajesh Chandramohanadas
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

2.  Analysis of two novel 1-4 quinolinone structures with bromine and nitrobenzyl ligands.

Authors:  Lidiane J Michelini; Wesley F Vaz; Giulio D C D'Oliveira; Caridad N Pérez; Hamilton B Napolitano
Journal:  J Mol Model       Date:  2019-02-08       Impact factor: 1.810

Review 3.  Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs - a review.

Authors:  Olayinka O Ajani; King T Iyaye; Olabisi T Ademosun
Journal:  RSC Adv       Date:  2022-06-24       Impact factor: 4.036

4.  Synthesis and Anticancer Properties of New 3-Methylidene-1-sulfonyl-2,3-dihydroquinolin-4(1H)-ones.

Authors:  Agata Jaskulska; Katarzyna Gach-Janczak; Joanna Drogosz-Stachowicz; Tomasz Janecki; Anna Ewa Janecka
Journal:  Molecules       Date:  2022-06-03       Impact factor: 4.927

5.  Remarkable Nonlinear Properties of a Novel Quinolidone Derivative: Joint Synthesis and Molecular Modeling.

Authors:  Clodoaldo Valverde; Rafael S Vinhal; Luiz F N Naves; Jean M F Custódio; Basílio Baseia; Heibbe Cristhian B de Oliveira; Caridad N Perez; Hamilton B Napolitano; Francisco A P Osório
Journal:  Molecules       Date:  2022-04-07       Impact factor: 4.927

Review 6.  A review on the synthesis of heteroannulated quinolones and their biological activities.

Authors:  Yaseen A M M Elshaier; Ashraf A Aly; Mohamed Abd El-Aziz; Hazem M Fathy; Alan B Brown; Mohamed Ramadan
Journal:  Mol Divers       Date:  2021-10-26       Impact factor: 3.364

7.  Weak Base-Promoted Lactamization under Microwave Irradiation: Synthesis of Quinolin-2(1H)-ones and Phenanthridin-6(5H)-ones.

Authors:  Pham Duy Quang Dao; Ho-Jin Lim; Chan Sik Cho
Journal:  ACS Omega       Date:  2018-09-27

8.  DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate.

Authors:  Hui Chen; Peng Li; Rongfei Qin; Hong Yan; Gang Li; Haihong Huang
Journal:  ACS Omega       Date:  2020-04-16

9.  Efficient Regioselective Synthesis of Novel Water-Soluble 2H,3H-[1,4]thiazino[2,3,4-ij]quinolin-4-ium Derivatives by Annulation Reactions of 8-quinolinesulfenyl Halides.

Authors:  Vladimir A Potapov; Roman S Ishigeev; Svetlana V Amosova
Journal:  Molecules       Date:  2021-02-20       Impact factor: 4.411

10.  Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays.

Authors:  Cristian O Salas; Ana Maria Zarate; Vladimir Kryštof; Jaime Mella; Mario Faundez; Jose Brea; María Isabel Loza; Ivan Brito; Denisa Hendrychová; Radek Jorda; Alan R Cabrera; Ricardo A Tapia; Christian Espinosa-Bustos
Journal:  Int J Mol Sci       Date:  2019-12-25       Impact factor: 5.923
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