Literature DB >> 2553224

Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells.

H Kumagai1, H Sakamoto, S Guggino, C R Filburn, B Sacktor.   

Abstract

The nervous system may play a role in regulation of bone metabolism. The effects of norepinephrine(NE), vasoactive intestinal peptide(VIP), and ATP on cytosolic Ca2+ were assessed in a rat osteoblast-like osteosarcoma cell line (UMR-106) responsive to PTH. All three transmitters transiently increased Ca2+, with ATP much greater than PTH greater than NE = VIP, and then caused sustained increases in Ca2+. The ATP-induced transient resulted from mobilization of intracellular Ca2+ store, while NE and VIP-induced transients also involved influx of Ca2+. Later sustained increases by all agonists were dependent upon extracellular Ca2+. Release of intracellular Ca2+ by ATP was associated with a marked increase in IP3 but without a significant change in cAMP. NE, VIP, and ATP, through regulation of Ca2+ metabolism, may be involved in various osteoporotic conditions.

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Year:  1989        PMID： 2553224     DOI： 10.1007/BF02556045

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  24 in total

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Authors:  S S Miller; A M Wolf; C D Arnaud
Journal:  Science       Date:  1976-06-25       Impact factor: 47.728

Review 2.  Mechanisms involved in alpha-adrenergic phenomena.

Authors:  J H Exton
Journal:  Am J Physiol       Date:  1985-06

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Authors:  E L Hohmann; L Levine; A H Tashjian
Journal:  Endocrinology       Date:  1983-04       Impact factor: 4.736

4.  Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells.

Authors:  I R Reid; R Civitelli; L R Halstead; L V Avioli; K A Hruska
Journal:  Am J Physiol       Date:  1987-07

5.  Parathyroid hormone and prostaglandin E2 stimulate both inositol phosphates and cyclic AMP accumulation in mouse osteoblast cultures.

Authors:  R W Farndale; J R Sandy; S J Atkinson; S R Pennington; S Meghji; M C Meikle
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

6.  Prostaglandins change cell shape and increase intercellular gap junctions in osteoblasts cultured from rat fetal calvaria.

Authors:  V Shen; L Rifas; G Kohler; W A Peck
Journal:  J Bone Miner Res       Date:  1986-06       Impact factor: 6.741

7.  Osteopenia and metatarsal fractures in diabetic neuropathy.

Authors:  T F Cundy; M E Edmonds; P J Watkins
Journal:  Diabet Med       Date:  1985-11       Impact factor: 4.359

8.  Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate.

Authors:  T Meyer; D Holowka; L Stryer
Journal:  Science       Date:  1988-04-29       Impact factor: 47.728

9.  Phenylalkylamine-sensitive calcium channels in osteoblast-like osteosarcoma cells. Characterization by ligand binding and single channel recordings.

Authors:  S E Guggino; J A Wagner; A M Snowman; L D Hester; B Sacktor; S H Snyder
Journal:  J Biol Chem       Date:  1988-07-25       Impact factor: 5.157

10.  Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels.

Authors:  D T Yamaguchi; T J Hahn; A Iida-Klein; C R Kleeman; S Muallem
Journal:  J Biol Chem       Date:  1987-06-05       Impact factor: 5.157
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  6 in total

1.  Dynamic redistribution of paxillin in bovine osteoblasts stimulated with adenosine 5'-triphosphate.

Authors:  Ann-Sophie Silber; Bastian Pfau; Toh Weng Tan; Ralf Jacob; David Jones; Thomas Meyer
Journal:  J Mol Histol       Date:  2012-05-05       Impact factor: 2.611

Review 2.  Purinergic signalling in the musculoskeletal system.

Authors:  Geoffrey Burnstock; Timothy R Arnett; Isabel R Orriss
Journal:  Purinergic Signal       Date:  2013-08-14       Impact factor: 3.765

3.  ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1).

Authors:  S Shimegi
Journal:  Calcif Tissue Int       Date:  1996-02       Impact factor: 4.333

4.  Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro.

Authors:  Mark O R Hajjawi; Jessal J Patel; Michelangelo Corcelli; Timothy R Arnett; Isabel R Orriss
Journal:  Purinergic Signal       Date:  2016-02-10       Impact factor: 3.765

Review 5.  Adenosine and bone metabolism.

Authors:  Aránzazu Mediero; Bruce N Cronstein
Journal:  Trends Endocrinol Metab       Date:  2013-03-14       Impact factor: 12.015

6.  Osteoblasts develop from isolated fetal mouse chondrocytes when co-cultured in high density with brain tissue.

Authors:  C G Groot; C W Thesingh; A M Wassenaar; J P Scherft
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-08       Impact factor: 2.416
  6 in total

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