Alireza Radmanesh1, Amir A Zamani2, Stephen Whalen3, Yanmei Tie3, Ralph O Suarez3, Alexandra J Golby3. 1. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA. Electronic address: alireza.radmanesh@ucsf.edu. 2. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA. 3. Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA.
Abstract
OBJECTIVES: To compare five different seeding methods to delineate hand, foot, and lip components of the corticospinal tract (CST) using single tensor tractography. METHODS: We studied five healthy subjects and 10 brain tumor patients. For each subject, we used five different seeding methods, from (1) cerebral peduncle (CP), (2) posterior limb of the internal capsule (PLIC), (3) white matter subjacent to functional MRI activations (fMRI), (4) whole brain and then selecting the fibers that pass through both fMRI and CP (WBF-CP), and (5) whole brain and then selecting the fibers that pass through both fMRI and PLIC (WBF-PLIC). Two blinded neuroradiologists rated delineations as anatomically successful or unsuccessful tractography. The proportions of successful trials from different methods were compared by Fisher's exact test. RESULTS: To delineate hand motor tract, seeding through fMRI activation areas was more effective than through CP (p<0.01), but not significantly different from PLIC (p>0.1). WBF-CP delineated hand motor tracts in a larger proportion of trials than CP alone (p<0.05). Similarly, WBF-PLIC depicted hand motor tracts in a larger proportion of trials than PLIC alone (p<0.01). Foot motor tracts were delineated in all trials by either PLIC or whole brain seeding (WBF-CP and WBF-PLIC). Seeding from CP or fMRI activation resulted in foot motor tract visualization in 87% of the trials (95% confidence interval: 60-98%). The lip motor tracts were delineated only by WBF-PLIC and in 36% of trials (95% confidence interval: 11-69%). CONCLUSIONS: Whole brain seeding and then selecting the tracts that pass through two anatomically relevant ROIs can delineate more plausible hand and lip motor tracts than seeding from a single ROI. Foot motor tracts can be successfully delineated regardless of the seeding method used.
OBJECTIVES: To compare five different seeding methods to delineate hand, foot, and lip components of the corticospinal tract (CST) using single tensor tractography. METHODS: We studied five healthy subjects and 10 brain tumorpatients. For each subject, we used five different seeding methods, from (1) cerebral peduncle (CP), (2) posterior limb of the internal capsule (PLIC), (3) white matter subjacent to functional MRI activations (fMRI), (4) whole brain and then selecting the fibers that pass through both fMRI and CP (WBF-CP), and (5) whole brain and then selecting the fibers that pass through both fMRI and PLIC (WBF-PLIC). Two blinded neuroradiologists rated delineations as anatomically successful or unsuccessful tractography. The proportions of successful trials from different methods were compared by Fisher's exact test. RESULTS: To delineate hand motor tract, seeding through fMRI activation areas was more effective than through CP (p<0.01), but not significantly different from PLIC (p>0.1). WBF-CP delineated hand motor tracts in a larger proportion of trials than CP alone (p<0.05). Similarly, WBF-PLIC depicted hand motor tracts in a larger proportion of trials than PLIC alone (p<0.01). Foot motor tracts were delineated in all trials by either PLIC or whole brain seeding (WBF-CP and WBF-PLIC). Seeding from CP or fMRI activation resulted in foot motor tract visualization in 87% of the trials (95% confidence interval: 60-98%). The lip motor tracts were delineated only by WBF-PLIC and in 36% of trials (95% confidence interval: 11-69%). CONCLUSIONS: Whole brain seeding and then selecting the tracts that pass through two anatomically relevant ROIs can delineate more plausible hand and lip motor tracts than seeding from a single ROI. Foot motor tracts can be successfully delineated regardless of the seeding method used.
Authors: Yun-Hee Kim; Dae-Shik Kim; Ji Heon Hong; Chang Hyun Park; Ning Hua; Kevin C Bickart; Woo Mok Byun; Sung Ho Jang Journal: Neuroreport Date: 2008-05-28 Impact factor: 1.837
Authors: Lorenzo Bello; Anna Gambini; Antonella Castellano; Giorgio Carrabba; Francesco Acerbi; Enrica Fava; Carlo Giussani; Marcello Cadioli; Valeria Blasi; Alessandra Casarotti; Costanza Papagno; Arun K Gupta; Sergio Gaini; Giuseppe Scotti; Andrea Falini Journal: Neuroimage Date: 2007-08-29 Impact factor: 6.556
Authors: P Ellen Grant; Kiho Im; Banu Ahtam; Cynthia T Laurentys; Wai-Man Chan; Maya Brainard; Sheena Chew; Marie Drottar; Caroline D Robson; Irene Drmic; Elizabeth C Engle Journal: Cereb Cortex Date: 2019-07-22 Impact factor: 5.357
Authors: Robert J Young; Ek T Tan; Kyung K Peck; Mehrnaz Jenabi; Sasan Karimi; Nicole Brennan; Jennifer Rubel; John Lyo; Weiji Shi; Zhigang Zhang; Marcel Prastawa; Xiaofeng Liu; Jonathan I Sperl; Robin Fatovic; Luca Marinelli; Andrei I Holodny Journal: Magn Reson Imaging Date: 2016-10-11 Impact factor: 2.546